Midazolam, the first benzodiazepine derivative with water-soluble salts, was studied as an
induction agent in general anesthesia for the elderly. In group 1 (n= 14), 5 or 10 mg oral …

The pharmacokinetic profile of 0.2 mg kg-1 midazolam given iv, for induction of anaesthesia,
was compared in young subjects and in those who were over 80 years of age. Thirty-five …

The pharmacokinetics of midazolam, an imidazo-benzodiazepine derivative, have been
studied in 13 subjects over the age of 60 years who received the drug intravenously (0.07 …

Midazolam, a new water‐soluble benzodiazepine, was investigated as an intravenous
anaesthetic agent in 260 adult patients in doses ranging from 0.15 to 0.5 mg/kg using a …

Intramuscular midazolam frequently results in excessive sedation in elderly patients. The
effects of preanesthetic medication with intramuscular midazolam were examined in 100 …

The pharmacokinetics and their relation to the pharmacodynamic properties of midazolam,
the first water-soluble benzodiazepine derivative, are reviewed. Pharmacokinetically …

Synopsis: Midazolam 1 is a short-acting water-soluble benzodiazepine (at pH< 4), a
member of a new class of imidazobenzodiazepine derivatives. At physiological pH the drug …

The chemistry, pharmacology, pharmacokinetics, clinical efficacy, adverse effects, drug
interactions, dosage, and cost and availability of midazolam hydrochloride are reviewed …

The effect of aging on the pharmacodynamics of midazolam was investigated in a double-
blinded study involving 39 consenting patients ranging in age from 39 to 77 yr. Midazolam …

Midazolam kinetics were determined in 11 younger (22 to 30 yr) and 11 older (50 to 60 yr)
women to determine age‐related differences in the kinetics of this water‐soluble …