ILF2 directly binds and stabilizes CREB to stimulate malignant phenotypes of liver cancer cells

H Du, Y Le, F Sun, K Li, Y Xu - Analytical Cellular Pathology, 2019 - Wiley Online Library
Cyclic adenosine monophosphate (cAMP) response element‐binding protein (CREB) is
overexpressed and has an oncogenic role in hepatocellular carcinoma (HCC). Interleukin …

Cyclic adenosine monophosphate-responsive element-binding protein activation predicts an unfavorable prognosis in patients with hepatocellular carcinoma

L Yu, P Zhang, R Qi, Z Li, S Zhang - OncoTargets and therapy, 2014 - Taylor & Francis
Aim To investigate the clinical significance of cyclic adenosine monophosphate-responsive
element-binding (CREB) and phosphorylated CREB (pCREB) expression in human …

[HTML][HTML] Expression and critical role of interleukin enhancer binding factor 2 in hepatocellular carcinoma

S Cheng, X Jiang, C Ding, C Du… - International journal of …, 2016 - mdpi.com
Interleukin enhancer binding factor 2 (ILF2), a transcription factor, regulates cell growth by
inhibiting the stabilization of mRNA. Currently, its role has gained recognition as a factor in …

Interferon regulatory factor 1 (IRF-1) activates anti-tumor immunity via CXCL10/CXCR3 axis in hepatocellular carcinoma (HCC)

Y Yan, L Zheng, Q Du, H Yazdani, K Dong, Y Guo… - Cancer letters, 2021 - Elsevier
Abstract Interferon regulatory factor 1 (IRF-1) is a tumor suppressor gene in cancer biology
with anti-proliferative and pro-apoptotic effect on cancer cells, however mechanisms of IRF-1 …

[HTML][HTML] CREB5 promotes cell proliferation and correlates with poor prognosis in hepatocellular carcinoma

J Wu, ST Wang, ZJ Zhang, Q Zhou… - International Journal of …, 2018 - ncbi.nlm.nih.gov
CAMP responsive element binding protein 5 (CREB5) has been reported to be
overexpressed in several types of human cancers and has crucial roles in regulating cell …

[HTML][HTML] Cellular retinol binding protein-1 inhibits cancer stemness via upregulating WIF1 to suppress Wnt/β-catenin pathway in hepatocellular carcinoma

X Liu, W Shan, T Li, X Gao, F Kong, H You, D Kong… - BMC cancer, 2021 - Springer
Background CRBP-1, a cytosolic chaperone of vitamin A, is identified in a serious number of
cancers; however, its biological role in hepatocellular carcinoma (HCC) needs to be further …

[HTML][HTML] CR6-interacting factor 1 inhibits invasiveness by suppressing TGF-β-mediated epithelial-mesenchymal transition in hepatocellular carcinoma

R Zhuang, D Lu, J Zhuo, X Zhang, K Wang, X Wei… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract CR6-interacting factor 1 (CRIF1) regulates cell cycle progression and the DNA
damage response. Here, we show that CRIF1 expression is decreased in hepatocellular …

[HTML][HTML] CRIF1 overexpression facilitates tumor growth and metastasis through inducing ROS/NFκB pathway in hepatocellular carcinoma

H Chang, J Li, K Qu, Y Wan, S Liu, W Zheng… - Cell death & …, 2020 - nature.com
ABSTRACT CR6-interacting factor 1 (Crif1) is a mitochondrial protein which is required for
the assembly of oxidative phosphorylation (OXPHOS) complexes. Our bioinformatics …

CRNDE-h transcript/miR-136-5p axis regulates interleukin enhancer binding factor 2 expression to promote hepatocellular carcinoma cell proliferation

TY Shiu, HH Lin, YL Shih, AC Feng, HH Huang… - Life Sciences, 2021 - Elsevier
Aims Hepatocellular carcinoma (HCC) is a primary malignancy of the hepatocyte. Interleukin
enhancer binding factor 2 (ILF2) plays a role in the development of HCC. However, the …

A pivotal role of cyclic AMP-responsive element binding protein in tumor progression

R Abramovitch, E Tavor, J Jacob-Hirsch, E Zeira… - Cancer research, 2004 - AACR
Tumor microenvironment controls the selection of malignant cells capable of surviving in
stressful and hypoxic conditions. The transcription factor, cyclic AMP-responsive element …