Phospholamban is concentrated in the nuclear envelope of cardiomyocytes and involved in perinuclear/nuclear calcium handling
Aims Phospholamban (PLB) regulates the cardiac Ca 2+-ATPase (SERCA2a) in
sarcoplasmic reticulum (SR). However, the localization of PLB at subcellular sites outside …
sarcoplasmic reticulum (SR). However, the localization of PLB at subcellular sites outside …
Phospholamban regulates nuclear Ca2+ stores and inositol 1, 4, 5-trisphosphate mediated nuclear Ca2+ cycling in cardiomyocytes
Aims Phospholamban (PLB) is the key regulator of the cardiac Ca 2+ pump (SERCA2a)-
mediated sarcoplasmic reticulum Ca 2+ stores. We recently reported that PLB is highly …
mediated sarcoplasmic reticulum Ca 2+ stores. We recently reported that PLB is highly …
[HTML][HTML] Association with SERCA2a directs phospholamban trafficking to sarcoplasmic reticulum from a nuclear envelope pool
W He, D Huang, S Guo, D Wang, J Guo, SE Cala… - Journal of Molecular and …, 2020 - Elsevier
Aims Phospholamban (PLB) stoichiometrically regulates the cardiac Ca 2+ pump
(SERCA2a) in the sarcoplasmic reticulum (SR); but in the nuclear envelope (NE) of …
(SERCA2a) in the sarcoplasmic reticulum (SR); but in the nuclear envelope (NE) of …
Phospholamban binds with differential affinity to calcium pump conformers
P Bidwell, DJ Blackwell, Z Hou, AV Zima… - Journal of Biological …, 2011 - ASBMB
To investigate the mechanism of regulation of sarco-endoplasmic reticulum Ca 2+-ATPase
(SERCA) by phospholamban (PLB), we expressed Cerulean-SERCA and yellow fluorescent …
(SERCA) by phospholamban (PLB), we expressed Cerulean-SERCA and yellow fluorescent …
Acute reversal of phospholamban inhibition facilitates the rhythmic whole-cell propagating calcium waves in isolated ventricular myocytes
Phospholamban (PLB) inhibits the activity of cardiac sarcoplasmic reticulum (SR) Ca 2+-
ATPase (SERCA2a). Phosphorylation of PLB during sympathetic activation reverses …
ATPase (SERCA2a). Phosphorylation of PLB during sympathetic activation reverses …
Enhanced phosphorylation of phospholamban and downregulation of sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in cardiac sarcoplasmic …
Objectives: To assess the phosphorylation of myocardial phospholamban (PLB) and
quantify protein levels of PLB and sarco/endoplasmic reticulum Ca2+ ATPase type 2 …
quantify protein levels of PLB and sarco/endoplasmic reticulum Ca2+ ATPase type 2 …
[HTML][HTML] Biophysical interaction between phospholamban and protein phosphatase 1 regulatory subunit GM
I Berrebi-Bertrand, M Souchet, JC Camelin, MP Laville… - FEBS letters, 1998 - Elsevier
Regulation of the sarco (endo) plasmic reticulum Ca2+-ATPase (SERCA 2a) depends on
the phosphorylation state of phospholamban (PLB). When PLB is phosphorylated, its …
the phosphorylation state of phospholamban (PLB). When PLB is phosphorylated, its …
Phospholamban overexpression in rabbit ventricular myocytes does not alter sarcoplasmic reticulum Ca transport
JR Waggoner, KS Ginsburg, B Mitton… - American Journal …, 2009 - journals.physiology.org
Phospholamban has been suggested to be a key regulator of cardiac sarcoplasmic
reticulum (SR) Ca cycling and contractility and a potential therapeutic target in restoring the …
reticulum (SR) Ca cycling and contractility and a potential therapeutic target in restoring the …
Phospholamban and sarcolipin: Are they functionally redundant or distinct regulators of the Sarco (Endo) Plasmic Reticulum Calcium ATPase?
Abstract In muscle, the Sarco (Endo) plasmic Reticulum Calcium ATPase (SERCA) activity is
regulated by two distinct proteins, PLB and SLN, which are highly conserved throughout …
regulated by two distinct proteins, PLB and SLN, which are highly conserved throughout …
Reconstitution of the cytoplasmic interaction between phospholamban and Ca2+-ATPase of cardiac sarcoplasmic reticulum
Y Kimura, M Inui - Molecular pharmacology, 2002 - ASPET
Phospholamban (PLN) reversibly inhibits the Ca2+-ATPase of cardiac sarcoplasmic
reticulum (SERCA2a) through a direct protein-protein interaction, playing a pivotal role in the …
reticulum (SERCA2a) through a direct protein-protein interaction, playing a pivotal role in the …