Metabolic adaptations are intimately associated with changes in cell behavior. Cancers are
characterized by a high metabolic plasticity resulting from mutations and the selection of …

Metabolic changes accompany tumor progression and metastatic dissemination of cancer
cells. Yet, until recently, metabolism has received little attention in the study of cancer …

Cancer cells acquire an unusual glycolytic behavior relative, to a large extent, to their
intracellular alkaline pH (pH i). This effect is part of the metabolic alterations found in most, if …

Metabolic reprogramming is a hallmark of cancer metastasis in which cancer cells
manipulate their metabolic profile to meet the dynamic energetic requirements of the tumor …

Background It has been known for close to a century that, on average, tumors have a
metabolism that is different from those found in healthy tissues. Typically, tumors show a …

Cancers progress through a series of events that can be characterized as “somatic
evolution.” A central premise of Darwinian evolutionary theory is that the environment …

Tumor cells carry various genetic and metabolic alterations, which directly contribute to their
growth and malignancy. Links between metabolism and cancer are multifaceted. Metabolic …

Cancer is a genetic disease that is caused by mutations in oncogenes, tumor suppressor
genes and stability genes. The fact that the metabolism of tumor cells is altered has been …

About a century ago Otto Warburg observed that tumor cells exhibited increased glycolysis
despite the presence of oxygen and stated this metabolic shift to glycolysis as the origin of …

Tumorigenesis is dependent on the reprogramming of cellular metabolism as both direct
and indirect consequence of oncogenic mutations. A common feature of cancer cell …