Gastric cancer is one of the most common malignant diseases, and poses a serious threat to
the quality of human life. Gastric cancer stem/progenitor cells (GCSPCs) have critical effects …

Background Delta-like ligand 4 (DLL4)-Notch signaling plays a key role in tumor
neovascular development and angiogenesis during tumor growth. The clinical significance …

Abstract δ‑Like ligand 4 (DLL4) has recently been reported to be involved in the process of
cancer angiogenesis and considered to play a vital role in vascular endothelial growth factor …

AIM: To investigate the potential roles of Delta-like ligand 4 (DLL4) on the biological
behavior of gastric cancer cells and its molecular mechanisms. METHODS: A recombinant …

Background: Emerging evidence suggests that delta-like ligand 4 (DLL4) and other
members of the Notch pathway may offer new targets for development of anti-angiogenesis …

Background Previous studies have shown the prognostic value of delta like canonical Notch
ligand 3 (DLL3) in patients with different types of tumors, but the role and predictive value of …

The Notch signaling pathway drives proliferation, differentiation, apoptosis, cell fate, and
maintenance of stem cells in several tissues. Aberrant activation of Notch signaling has …

Delta‐like protein 3 (DLL 3) is a ligand of Notch signaling, which mediates cell‐fate
decisions and is tumor‐suppressive or oncogenic depending on the cellular context …

The stubborn chemoresistance of pancreatic ductal adenocarcinoma (PDA) is
simultaneously influenced by tumor parenchymal and stromal factors, and the ctritical role of …

Simple Summary Over 70% of breast cancers (BCs) are estrogen receptor-positive (ER+).
The development of endocrine therapy has considerably improved patient outcomes …