The optic nerve crush injury is a well-accepted model to study the mechanisms of axonal
regeneration after trauma in the CNS. The infection of retinal ganglion cells (RGCs) with an …

The use of the visual system played a major role in the elucidation of molecular mechanisms
controlling axonal regeneration in the injured CNS after trauma. In this model, CNTF was …

Rat optic nerve (ON) transection leads to mainly apoptotic cell death of about 85% of the
retinal ganglion cell (RGC) population within 14 days after lesion. In the present study, we …

We used a gene therapy approach in transgenic mice to assess the cooperative effects of
combining anti‐apoptotic and growth‐promoting stimuli on adult retinal ganglion cell (RGC) …

In diseases such as glaucoma, the failure of retinal ganglion cell (RGC) neurons to survive
or regenerate their optic nerve axons underlies partial and, in some cases, complete vision …

Recombinant adeno-associated viral (rAAV) vectors expressing neurotrophic genes reduce
neuronal death and promote axonal regeneration in central nervous system (CNS) injury …

Ciliary neurotrophic factor (CNTF) has been shown to protect ganglion cells in a variety of
acute ischaemia models. Here we assess the efficacy of local CNTF gene transfer in …

Purpose.: To analyze the neuroprotective effect of intravitreally grafted neural stem (NS)
cells genetically modified to secrete ciliary neurotrophic factor (CNTF) on intraorbitally …

Autologous peripheral nerves were transplanted onto transected optic nerves of adult mice.
We examined whether intraocular CNTF injections increased retinal ganglion cell (RGC) …

The aim of the present study was to determine whether adeno-associated viral vector (AAV)
mediated transfer of ciliary neurotrophic factor (CNTF) and RhoA shRNA has additive effects …