Background Neutrophilic inflammation is associated with poorly controlled asthma. Serum
levels of sST2, a soluble IL-33 receptor, increase in neutrophilic lung diseases. We …

Background: Previous murine models have demonstrated interleukin (IL)-33 to be an
important mediator of type-2 inflammation and to promote airway hyperresponsiveness in …

Purpose Suppression of tumorigenicity 2 (ST2) has been proposed as the receptor
contributing to neutrophilic inflammation in patients with type 2-low asthma. However, the …

Objective: Interleukin-33 is an IL-1 family cytokine which signals via its T1/ST2 receptor, and
acts as a key regulator of inflammation, notably the type-2 response implicated in asthma …

Interleukin-33 is a member of IL-1 family of cytokines and binds to two receptors: ST2 (IL-1-
R1) and IL-1 receptor accessory protein (IL-1RAP). There are two isoforms of ST2 proteins …

ABSTRACT Objective: Interleukin (IL)-33 is involved in the development of lung
inflammation by inducing or amplifying Th2 type-mediated responses in various animal …

It is clear that a hyperactive type 2 immune response contributes to the pathogenesis of
asthma in at least a subgroup of patients. Blood, sputum, and airway biomarkers of …

Chronic obstructive pulmonary disease (COPD) is an inflammatory condition with constantly
increasing mortality rates. Interleukin (IL)-33 and its decoy receptor, soluble suppression of …

IL33/ST2 axis activates airway eosinophils that exacerbate airway inflammation. The data
was obtained from PubMed, EMBASE, Clinical trial, Cochrane Library, Web of science, CNKI …

Allergic asthma is a chronic inflammatory disease of the airways that in some patients is
characterized by airway eosinophilia. IL-33 and thymic stromal lymphopoietin (TSLP) are …