Metabolic syndrome is nosographically defined by using clinical diagnostic criteria such as
those of the International Diabetes Federation (IDF) ones, including visceral adiposity, blood …

This paper reviews our present knowledge on the contribution of ceramide (Cer),
sphingomyelin (SM), dihydroceramide (DhCer) and sphingosine-1-phosphate (S1P) in …

Objective: Recent studies indicate that sphingolipids, sphingomyelin (SM) and ceramide
(Cer) are associated with the development of metabolic syndrome. However, detailed …

We used a HPLC-MS/MS methodology for determination of a basic metabolomic profile (18:
1, 18: 0 sphingoid backbone, C 14-C 26 N-acyl part) of" normal" sphingolipid levels in …

Aims/hypothesis Sphingolipid synthesis is typically initiated by the conjugation of l-serine
and palmitoyl-CoA, a reaction catalysed by serine palmitoyltransferase (SPT). SPT can also …

Sphingolipids are a family of lipid molecules produced through different pathways in
mammals. Sphingolipids are structural components of membranes, but in response to …

Sphingolipid metabolism is dysregulated in type 2 diabetes mellitus (T2DM); however, the
focus of previous studies was mostly limited to ceramide (Cer), and only few studies have …

Background: Sphingolipids are components of cell membrane structure, but also circulate in
serum and are essential mediators of many cellular functions. While ceramides have been …

Sphingolipids play an important role in the development of diabetes, both type 1 and type 2
diabetes, as well as in the development of both micro-and macro-vascular complications …

Context Ceramides and sphingolipids have been linked to type 2 diabetes (T2D). The
Ceramides and Sphingolipids as Predictors of Incident Dysglycemia (CASPID) study is …