Abstract Background and Objective Human carboxylesterase-1 (CES1) and human
carboxylesterase-2 (CES2) play an important role in metabolizing many medications …

Abstract Background and Objective Human carboxylesterase-1 (CES1) is an enzyme that is
primarily expressed in the liver, where it plays an important role in the metabolism of many …

Background Human carboxylesterase 1 (CES1) is a serine esterase that hydrolyses various
exogenous and endogenous compounds including oseltamivir, a prodrug used to treat …

Oseltamivir phosphate is an ethyl ester prodrug widely used in the treatment and prevention
of both Influenzavirus A and B infections. The conversion of oseltamivir to its active …

Carboxylesterase 1 (CES1) is the major hepatic hydrolytic enzyme responsible for the
metabolism of many therapeutic agents, toxins, and endogenous compounds existing as …

Bioactivation of the antiviral agent oseltamivir to active oseltamivir carboxylate is catalyzed
by carboxylesterase 1 (CES1). After the screening of 860 healthy Finnish volunteers for the …

Background: Carboxylesterases (CES) play a critical role in catalyzing hydrolysis of esters,
amides, carbamates and thioesters, as well as bioconverting prodrugs and soft drugs. The …

Purpose The aim of this study was to examine whether carboxylesterase 1 (CES1A) genetic
polymorphisms affect the pharmacokinetics of oseltamivir. Methods Thirty healthy Japanese …

Carboxylesterase 1 (CES1) is the major hydrolase in human liver. The enzyme is involved in
the metabolism of several important therapeutic agents, drugs of abuse, and endogenous …

Oseltamivir, an inactive anti‐influenza virus prodrug, is activated (hydrolysed) in vivo by
carboxylesterase 1 (CES 1) to its active metabolite oseltamivir carboxylate. CES 1 functions …