CYP3A5* 3 and C3435T MDR1 polymorphisms in prognostication of drug‐resistant epilepsy in children and adolescents
E Emich-Widera, W Likus, B Kazek… - BioMed research …, 2013 - Wiley Online Library
Drug‐resistant epilepsies still remain one of the most profound problems of contemporary
epileptology. Several mechanisms of drug resistance are possible; among them, genetic …
epileptology. Several mechanisms of drug resistance are possible; among them, genetic …
Genetic contribution of CYP1A1 variant on treatment outcome in epilepsy patients: a functional and interethnic perspective
CYP1A1 gene is involved in estrogen metabolism, and previously, we have reported
association of variant rs2606345 with altered anti-epileptic drugs (AED) response in North …
association of variant rs2606345 with altered anti-epileptic drugs (AED) response in North …
Pharmacogenetic Variants and Plasma Concentrations of Antiseizure Drugs: A Systematic Review and Meta-Analysis
F Milosavljević, M Manojlović, L Matković… - JAMA Network …, 2024 - jamanetwork.com
Importance Precise estimation of a patient's drug metabolism capacity is important for
antiseizure dose personalization. Objective To quantify the differences in plasma …
antiseizure dose personalization. Objective To quantify the differences in plasma …
Genetic polymorphism of CYP2C9 and CYP2C19 in a Bolivian population: an investigative and comparative study
HV Bravo-Villalta, K Yamamoto, K Nakamura… - European journal of …, 2005 - Springer
Objective Several reports of CYP2C genetic polymorphism demonstrate its potential clinical
role in determining both inter-individual and inter-ethnic differences in drug efficacy. We …
role in determining both inter-individual and inter-ethnic differences in drug efficacy. We …
Association of polymorphisms in the cytochrome P450 (CYP) 2C19 and 2C18 genes in Japanese epileptic patients
K Mamiyaa, I Ieiria, S Miyaharaa, J Imaia… - Pharmacogenetics …, 1998 - journals.lww.com
The human cytochrome P450 2C subfamily is one of the major subfamilies in the human
liver, and four members of this subfamily have been identified: CYP2C8, CYP2C9 …
liver, and four members of this subfamily have been identified: CYP2C8, CYP2C9 …
The Effects of genetic polymorphisms of CYP2C9 and CYP2C 19 on phenytoin metabolism in Japanese adult patients with epilepsy: studies in stereoselective …
K Mamiya, I Ieiri, J Shimamoto, E Yukawa, J Imai… - …, 1998 - Wiley Online Library
Purpose: The aim of this study was to clarify the effects of genetic polymorphisms of
cytochrome P450 (CYP) 2C9 and 2C19 on the metabolism of phenytoin (PHT). In addition, a …
cytochrome P450 (CYP) 2C9 and 2C19 on the metabolism of phenytoin (PHT). In addition, a …
Impact of genetic polymorphisms on phenytoin pharmacokinetics and clinical outcomes in the Middle East and North Africa Region
Background Genetic polymorphisms are known to influence outcomes with phenytoin yet
effects in the Middle East and North Africa region are poorly understood. Objectives The …
effects in the Middle East and North Africa region are poorly understood. Objectives The …
Neurological toxicity after phenytoin infusion in a pediatric patient with epilepsy: influence of CYP2C9, CYP2C19 and ABCB1 genetic polymorphisms
P Dorado, E López-Torres, EM Peñas-Lledó… - The …, 2013 - nature.com
Pharmacogenetic studies have shown that genetic defects in drug-metabolizing enzymes
encoded by CYP2C9, CYP2C19 genes and by the transporter ABCB1 gene can influence …
encoded by CYP2C9, CYP2C19 genes and by the transporter ABCB1 gene can influence …
[PDF][PDF] Association of polymorphisms of CYP2C9, CYP2C19, and ABCB1, and activity of P-glycoprotein with response to anti-epileptic drugs.
SR Taur, NB Kulkarni, PP Gandhe… - Journal of …, 2014 - researchgate.net
ABSTRACT Background and Objective: Epilepsy, the most common neurological disorder,
has treatment failure rate of 20 to 25%. Inter-individual variability in drug response can be …
has treatment failure rate of 20 to 25%. Inter-individual variability in drug response can be …
[PDF][PDF] Prevalence of CYP2B6 polymorphisms in Argentinians: the role of genetic testing
P Scibona, C Vazquez, AR Cajal… - Genetics and …, 2015 - researchgate.net
CYP2B6 is a highly polymorphic isoenzyme involved in the metabolism of many drugs
including cyclophosphamide, bupropion, and efavirenz. A single nucleotide polymorphism …
including cyclophosphamide, bupropion, and efavirenz. A single nucleotide polymorphism …