Drug‐resistant epilepsies still remain one of the most profound problems of contemporary
epileptology. Several mechanisms of drug resistance are possible; among them, genetic …

CYP1A1 gene is involved in estrogen metabolism, and previously, we have reported
association of variant rs2606345 with altered anti-epileptic drugs (AED) response in North …

Importance Precise estimation of a patient's drug metabolism capacity is important for
antiseizure dose personalization. Objective To quantify the differences in plasma …

Objective Several reports of CYP2C genetic polymorphism demonstrate its potential clinical
role in determining both inter-individual and inter-ethnic differences in drug efficacy. We …

The human cytochrome P450 2C subfamily is one of the major subfamilies in the human
liver, and four members of this subfamily have been identified: CYP2C8, CYP2C9 …

Purpose: The aim of this study was to clarify the effects of genetic polymorphisms of
cytochrome P450 (CYP) 2C9 and 2C19 on the metabolism of phenytoin (PHT). In addition, a …

Background Genetic polymorphisms are known to influence outcomes with phenytoin yet
effects in the Middle East and North Africa region are poorly understood. Objectives The …

Pharmacogenetic studies have shown that genetic defects in drug-metabolizing enzymes
encoded by CYP2C9, CYP2C19 genes and by the transporter ABCB1 gene can influence …

ABSTRACT Background and Objective: Epilepsy, the most common neurological disorder,
has treatment failure rate of 20 to 25%. Inter-individual variability in drug response can be …

CYP2B6 is a highly polymorphic isoenzyme involved in the metabolism of many drugs
including cyclophosphamide, bupropion, and efavirenz. A single nucleotide polymorphism …