Microtubule Dynamics: Mechanism, Regulation, and Function Page 1 Annu. Rev. Cell BioI. /99/.
7: 93-//6 Copyright © /99/ by Annual Reviews Inc. All rights reserved MICROTUBULE DYNAMICS …

A phenotype-based screen identifies a purine analog, named diminutol, that perturbs the
microtubule cytoskeleton in cells. An affinity-based approach identifies a protein target of this …

Microtubules, the largest and the most rigid of the cytoskeletal filaments, are responsible for
intracellular organization and cellular morphology. The mechanical and dynamical …

Microtubule stabilizing agents (MSAs) comprise a class of drugs that bind to microtubule
(MT) polymers and stabilize them against disassembly. Several of these agents are currently …

Microtubules are dynamic cellular polymers. Their dynamics are exquisitely regulated and
are essential to many cellular activities including mitosis, cell division, signaling, adhesion …

Dynamic instability is a hallmark of the microtubule cytoskeleton. In order to regulate
microtubule dynamics in vivo, a varied host of microtubule-associated proteins are mobilized …

Microtubules are cylindrical, cytoskeletal protein polymers found in all eukaryotic cells. They
perform a plethora of functions associated with cellular structure, organization, and …

The cytoskeleton is a network of intracellular protein filaments that constructs and maintains
a cellular architecture. Microtubules (MT) are one of the three types of the cytoskeleton, and …

The essential microtubule property of dynamic instability is based on the binding, hydrolysis
and exchange of GTP in each tubulin dimer. The recent high-resolution structures of tubulin …