Aging has been associated with oxidative stress and the accumulation of mitochondrial DNA
(mtDNA) mutation. The previous study has established a mimetic rat model of aging using d …

Presbycusis has become a common sensory deficit in humans. Oxidative damage to
mitochondrial DNA and mitochondrial dysfunction is strongly associated with the aging of …

Chronic administration of D‑galactose (D‑gal) is a useful method for establishing a model of
natural aging in the auditory system. Previous studies have demonstrated that NADPH …

Oxidative damage to mitochondrial DNA (mtDNA) and cell apoptosis are heavily implicated
in aging. Our previous study established a mimetic rat model of aging in the cochleae using …

Background Age-related hearing loss, known as presbycusis, is the result of auditory system
degeneration. Numerous studies have suggested that reactive oxygen species (ROS) and …

Aging has been associated with mitochondrial DNA (mtDNA) common deletion (CD). Age
changes in the central auditory system are well known to affect speech perception. Base …

Presbycusis results from age-related degeneration of the auditory system. D-galactose (D-
gal)-induced aging is an ideal and commonly used animal model in aging research …

One of the most common complaints among aging individuals is difficulty in understanding
speech in a compromised listening environment, such as when background noise is …

The age-related deterioration in the central auditory system is well known to impair the
abilities of sound localization and speech perception. However, the mechanisms involved in …

The cochlear basilar membrane (CBM) contains inner hair cells and outer hair cells that
convert sound waves into electrical signals and transmit them to the central auditory system …