RNA sequencing quantification of xenobiotic-processing genes in various sections of the intestine in comparison to the liver of male mice
ZD Fu, FP Selwyn, JY Cui, CD Klaassen - Drug Metabolism and Disposition, 2016 - ASPET
Previous reports on tissue distribution of xenobiotic-processing genes (XPGs) have
limitations, because many non–cytochrome P450 phase I enzymes have not been …
limitations, because many non–cytochrome P450 phase I enzymes have not been …
RNA-Seq profiling of intestinal expression of xenobiotic processing genes in germ-free mice
ZD Fu, FP Selwyn, JY Cui, CD Klaassen - Drug Metabolism and Disposition, 2017 - ASPET
Intestinal bacteria can affect xenobiotic metabolism through both direct bacterial enzyme-
catalyzed modification of the xenobiotics and indirect alterations of the expression of host …
catalyzed modification of the xenobiotics and indirect alterations of the expression of host …
[HTML][HTML] Hepatic xenobiotic metabolizing enzyme and transporter gene expression through the life stages of the mouse
Background Differences in responses to environmental chemicals and drugs between life
stages are likely due in part to differences in the expression of xenobiotic metabolizing …
stages are likely due in part to differences in the expression of xenobiotic metabolizing …
Developmental regulation of drug-processing genes in livers of germ-free mice
FP Selwyn, SL Cheng, TK Bammler… - Toxicological …, 2015 - academic.oup.com
Very little is known about the effect of gut microbiota on the ontogeny of drug-processing
genes (DPGs) in liver. In this study, livers were harvested from conventional (CV) and germ …
genes (DPGs) in liver. In this study, livers were harvested from conventional (CV) and germ …
Gene expression profiling of systems involved in the metabolism and the disposition of xenobiotics: comparison between human intestinal biopsy samples and colon …
J Bourgine, I Billaut-Laden, M Happillon… - Drug metabolism and …, 2012 - ASPET
Intestinal cell lines are used as in vitro models for pharmacological and toxicological studies.
However, a general report of the gene expression spectrum of proteins that are involved in …
However, a general report of the gene expression spectrum of proteins that are involved in …
Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues
P Pavek, Z Dvorak - Current drug metabolism, 2008 - ingentaconnect.com
Numerous members of the cytochrome P450 (CYP) superfamily are induced after exposure
to a variety of xenobiotics in human liver. We have gained considerable mechanistic insights …
to a variety of xenobiotics in human liver. We have gained considerable mechanistic insights …
[HTML][HTML] Cross-species analysis of hepatic cytochrome P450 and transport protein expression
Most drugs and xenobiotics are metabolized in the liver. Amongst others, different
cytochrome P450 (CYP) enzymes catalyze the metabolic conversion of foreign compounds …
cytochrome P450 (CYP) enzymes catalyze the metabolic conversion of foreign compounds …
Crypt organoid culture as an in vitro model in drug metabolism and cytotoxicity studies
W Lu, E Rettenmeier, M Paszek, MF Yueh… - Drug Metabolism and …, 2017 - ASPET
The gastrointestinal tract is enriched with xenobiotic processing proteins that play important
roles in xenobiotic bioactivation, metabolism, and detoxification. The application of …
roles in xenobiotic bioactivation, metabolism, and detoxification. The application of …
RNA-Seq quantification of hepatic drug processing genes in germ-free mice
FP Selwyn, JY Cui, CD Klaassen - Drug metabolism and disposition, 2015 - ASPET
Intestinal bacteria have been shown to be important in regulating host intermediary
metabolism and contributing to obesity. However, relatively less is known about the effect of …
metabolism and contributing to obesity. However, relatively less is known about the effect of …
Effects of aging on mRNA profiles for drug-metabolizing enzymes and transporters in livers of male and female mice
ZD Fu, IL Csanaky, CD Klaassen - Drug Metabolism and Disposition, 2012 - ASPET
Aging is a physiological process characterized by progressive functional decline in various
organs over time. To reveal possible molecular mechanisms of altered xenobiotic …
organs over time. To reveal possible molecular mechanisms of altered xenobiotic …