Background Oxidative stress due to purine degradation is associated with the development
of chronic heart failure (CHF). Xanthine oxidoreductase (XOR) is a rate-limiting enzyme of …

Aims Reactive oxygen species are reportedly involved in the mechanism underlying heart
failure with preserved ejection fraction (HFpEF); however, the disease pathophysiology …

Background and purpose Xanthine oxidoreductase (XOR), which catalyzes purine
catabolism, has two interconvertible forms, xanthine dehydrogenase and xanthine oxidase …

Aims Plasma xanthine oxidoreductase (XOR) activity during the acute phase of acute heart
failure (AHF) requires further elucidation. Methods and results One hundred eighteen AHF …

The pathophysiologic understanding of chronic heart failure (CHF) has shifted from a mere
hemodynamic disorder to a much more complex approach including changes and …

Increasing evidence suggests that serum uric acid (UA), a product of xanthine oxidase (XO),
may be a useful marker for metabolic, hemodynamic, and functional staging in heart failure …

Background—Oxidative stress may contribute to heart failure (HF) progression. Inhibiting
xanthine oxidase in hyperuricemic HF patients may improve outcomes. Methods and …

Heart failure (HF) is a state of chronic deterioration of oxidative mechanisms due to
enhanced oxidative stress and consequent subcellular alterations. In this condition, oxidant …

BACKGROUND: Reactive oxygen species (ROS) have been linked to hypertrophy,
remodeling and abnormal excitation-contraction coupling. Previous data demonstrated that …

The role of hyperuricaemia as cardiovascular risk factor has exhaustingly been debated for
decades. While the association of elevated uric acid (UA) levels with increased mortality risk …