Gap junctions and connexins in cancer formation, progression, and therapy
R Ruch - Cancers, 2020 - mdpi.com
The development of many forms of intercellular communication was essential for the
evolution of multicellular organisms. The organization of cells into tissues and organs and …
evolution of multicellular organisms. The organization of cells into tissues and organs and …
Gap junctions and cancer: communicating for 50 years
Fifty years ago, tumour cells were found to lack electrical coupling, leading to the hypothesis
that loss of direct intercellular communication is commonly associated with cancer onset and …
that loss of direct intercellular communication is commonly associated with cancer onset and …
Downregulation of gap junctions in cancer cells
E Leithe, S Sirnes, Y Omori… - Critical Reviews™ in …, 2006 - dl.begellhouse.com
Gap junctions are intercellular plasma membrane domains enriched in channels that allow
direct exchange of ions and small molecules between adjacent cells. Gap junction channels …
direct exchange of ions and small molecules between adjacent cells. Gap junction channels …
Implications and challenges of connexin connections to cancer
CC Naus, DW Laird - Nature Reviews Cancer, 2010 - nature.com
The idea that the gap junction family of proteins, connexins, are tumour suppressors has
been widely supported through numerous cancer models. However, the paradigm that …
been widely supported through numerous cancer models. However, the paradigm that …
Gap junctions as targets for cancer chemoprevention and chemotherapy
JE Trosko, RJ Ruch - Current Drug Targets, 2002 - ingentaconnect.com
The development of the most efficacious strategy for the prevention and treatment of cancers
is based on understanding the underlying mechanisms of carcinogenesis. This includes the …
is based on understanding the underlying mechanisms of carcinogenesis. This includes the …
Gap junctions and connexins as therapeutic targets in cancer
M Kandouz, G Batist - Expert opinion on therapeutic targets, 2010 - Taylor & Francis
Importance of the field: Connexins (Cxs) and gap junctional intercellular communications
(GJICs) play roles in cancer development, growth and metastasis. Experimental studies …
(GJICs) play roles in cancer development, growth and metastasis. Experimental studies …
Connexins and carcinogenesis
Cancer was the first pathology to be associated with a dysfunction of gap junctions, over 40
years ago. Since then, data supporting this association have accumulated without …
years ago. Since then, data supporting this association have accumulated without …
Gap junctions and cancer: new functions for an old story
Cancer was one of the first pathologies to be associated with gap-junction defect. Despite
the evidence accumulated over the last 40-year period, the molecular involvement of gap …
the evidence accumulated over the last 40-year period, the molecular involvement of gap …
Connexins in cancer: bridging the gap to the clinic
T Aasen, E Leithe, SV Graham, P Kameritsch… - Oncogene, 2019 - nature.com
Gap junctions comprise arrays of intercellular channels formed by connexin proteins and
provide for the direct communication between adjacent cells. This type of intercellular …
provide for the direct communication between adjacent cells. This type of intercellular …
Connexins in growth control and cancer
CC Naus, GS Goldberg, WC Sin - Gap junctions in development and …, 2005 - Springer
Gap junctions, and their constituent connexin proteins, have long been considered to play a
role in the control of cell growth and carcinogenesis. The current review will attempt to …
role in the control of cell growth and carcinogenesis. The current review will attempt to …