Background Multiple sclerosis is an autoimmune disease with a distinct female bias, as well
as a high prevalence of neuropathic pain in both sexes. The dorsal root ganglia (DRG) …

Multiple Sclerosis (MS) is an autoimmune disease with notable sex differences. Women are
not only more likely to develop MS but are also more likely than men to experience …

Microglia play an important role in the pathogenesis of multiple sclerosis and the mouse
model of MS, experimental autoimmune encephalomyelitis (EAE). To more fully understand …

Multiple sclerosis (MS) is an autoimmune, demyelinating disease of the central nervous
system. Patients with MS typically present with visual, motor, and sensory deficits. However …

Background Microglia have been implicated in the pathophysiology of neuropathic pain.
Here, we sought to investigate whether cerebrospinal fluid (CSF) might be used as a proxy …

Central nervous system (CNS) inflammation is a key factor in multiple sclerosis (MS).
Invasion of peripheral immune cells into the CNS resulting from an unknown signal or …

Activation of microglia in the spinal cord following peripheral nerve injury is critical for the
development of long-lasting pain hypersensitivity. However, it remains unknown whether …

Activation of microglia in the spinal cord following peripheral nerve injury is critical for the
development of long-lasting pain hypersensitivity. However, it remains unclear whether …

In this review, we report existing preclinical evidence on how the CNS compartment as well
as sex affect microglia functions in health. We highlight that recent advances in …

An increasing amount of evidence points to an important role of macrophages in peripheral
nerve injury (PNI) and associated pain. Peripheral nerve macrophages facilitate the …