Altered mitochondrial respiration, morphology, and quality control collectively contribute to
mitochondrial dysfunction in the aged heart. Because myocardial infarction remains the …

The incidence of myocardial infarction rises sharply at menopause, implicating a potential
role for estrogen (E2) loss in age-related increases in ischemic injury. We aimed to identify …

The incidence of cardiovascular disease and metabolic syndrome increases after the onset
of menopause, suggesting estrogen has a vital role in their prevention. Mitochondrial …

Despite conflicting evidence for the efficacy of hormone replacement therapy in
cardioprotection of postmenopausal women, numerous studies have demonstrated …

Increased susceptibility to stress-induced myocardial damage is a significant concern in
addition to decreased cardiac performance in postmenopausal females. To determine the …

BACKGROUND: Cardiovascular disease mortality increases rapidly after menopause by
poorly defined mechanisms. OBJECTIVE: Because mitochondrial function and Ca2+ …

Anecdotal and scientific evidence suggest that the sex hormone estrogen provides
significant health benefits in women. Women have higher estrogen levels than men …

Sex‐specific differences in mitochondrial function and free radical homeostasis are reported
in the context of aging but not well‐established in pathogeneses occurring early in life. Here …

Old age is a major risk factor for cardiovascular diseases. Several lines of evidence in
experimental animal models have indicated the central role of mitochondria both in lifespan …

Increased susceptibility to permeability transition pore (mPTP) is a significant concern to
decreased cardiac performance in postmenopausal females. The goal of this study was to …