The role of monocytes and macrophages in acute and acute-on-chronic liver failure

E Triantafyllou, KJ Woollard, MJW McPhail… - Frontiers in …, 2018 - frontiersin.org
Acute and acute-on-chronic liver failure (ALF and ACLF), though distinct clinical entities, are
considered syndromes of innate immune dysfunction. Patients with ALF and ACLF display …

Leukocytes, systemic inflammation and immunopathology in acute-on-chronic liver failure

M Casulleras, IW Zhang, C López-Vicario, J Clària - Cells, 2020 - mdpi.com
Acute-on-chronic liver failure (ACLF) is a complex syndrome that develops in patients with
cirrhosis and is characterized by acute decompensation, organ failure (s) and high short …

The acute-on-chronic liver failure syndrome, or when the innate immune system goes astray

J Clària, V Arroyo, R Moreau - The Journal of Immunology, 2016 - journals.aai.org
The acute-on-chronic liver failure (ACLF) syndrome is characterized by acute
decompensation of cirrhosis, organ failure, and high 28-d mortality. ACLF displays key …

Mechanisms of immunity in acutely decompensated cirrhosis and acute‐on‐chronic liver failure

C Engelmann, IW Zhang, J Clària - Liver International, 2023 - Wiley Online Library
The identification of systemic inflammation (SI) as a central player in the orchestration of
acute‐on‐chronic liver failure (ACLF) has opened new avenues for the understanding of the …

[HTML][HTML] Role of monocytes and macrophages in experimental and human acute liver failure

LA Possamai, CG Antoniades, QM Anstee… - World Journal of …, 2010 - ncbi.nlm.nih.gov
Acute liver failure (ALF) is a devastating clinical syndrome characterised by progressive
encephalopathy, coagulopathy, and circulatory dysfunction, which commonly leads to …

[HTML][HTML] Modulation of monocyte/macrophage function: a therapeutic strategy in the treatment of acute liver failure

LA Possamai, MR Thursz, JA Wendon… - Journal of …, 2014 - Elsevier
Acute liver failure (ALF) is a condition with a high mortality and morbidity for which new
treatments are desperately required. We contend that although the initial event in ALF is liver …

Dysfunctional immune response in acute-on-chronic liver failure: it takes two to tango

R Martin-Mateos, M Alvarez-Mon, A Albillos - Frontiers in immunology, 2019 - frontiersin.org
Acute-on-chronic liver failure (ACLF) is characterized by the acute decompensation of
cirrhosis associated with organ failure and high short-term mortality. The key event in the …

Acute liver failure: mechanisms of immune‐mediated liver injury

Z Wu, M Han, T Chen, W Yan, Q Ning - Liver International, 2010 - Wiley Online Library
Acute liver failure (ALF) is a syndrome of diverse aetiology, including hepatic
encephalopathy, renal, cardiac and pulmonary failures, which result in a rapid loss of …

[HTML][HTML] The importance of immune dysfunction in determining outcome in acute liver failure

CG Antoniades, PA Berry, JA Wendon, D Vergani - Journal of hepatology, 2008 - Elsevier
Acute liver failure (ALF) shares striking similarities with septic shock with regard to the
features of systemic inflammation, progression to multiple organ dysfunction and functional …

Pathogenesis of liver injury in acute liver failure

RT Chung, RT Stravitz, RJ Fontana, FV Schiodt… - …, 2012 - gastrojournal.org
Acute liver failure (ALF) represents the most severe damage an organ can sustain and can
lead to shock, coagulopathy, altered mentation, cerebral edema, renal failure, infection, and …