[图书][B] Identification, and Characterization of Novel Inhibitors of the Presynaptic, Hemicholinium-3-Sensitive Choline Transporter
EA Ennis - 2016 - search.proquest.com
The neurotransmitter acetylcholine (ACh), acting on both muscarinic and nicotinic receptors
in the central and peripheral nervous systems, controls or modulates virtually every …
in the central and peripheral nervous systems, controls or modulates virtually every …
A Novel Approach to Cholinergic Signaling Modulation: Development and Characterization of ML352, a Novel, Noncompetitive Inhibitor of the Presynaptic Choline …
E Ennis, J Wright, J Tarr, C Locuson… - The FASEB …, 2015 - Wiley Online Library
The choline transporter (CHT) is a critical determinant of acetylcholine (ACh) synthesis and
signaling. Despite the medicinal uses of anticholinergics, CHT remains a largely unexplored …
signaling. Despite the medicinal uses of anticholinergics, CHT remains a largely unexplored …
[图书][B] Identification, subcellular localization and targeted disruption of the presynaptic, hemicholinium-3-sensitive choline transporter
SM Ferguson - 2004 - search.proquest.com
Presynaptic synthesis of acetylcholine (ACh) requires a steady supply of choline, acquired
by a plasma membrane, hemicholinium-3 (HC-3) sensitive choline transporter (CHT). In the …
by a plasma membrane, hemicholinium-3 (HC-3) sensitive choline transporter (CHT). In the …
Identification and characterization of ML352: a novel, noncompetitive inhibitor of the presynaptic choline transporter
EA Ennis, J Wright, CL Retzlaff… - ACS chemical …, 2015 - ACS Publications
The high-affinity choline transporter (CHT) is the rate-limiting determinant of acetylcholine
(ACh) synthesis, yet the transporter remains a largely undeveloped target for the detection …
(ACh) synthesis, yet the transporter remains a largely undeveloped target for the detection …
[HTML][HTML] Discovery of compounds that positively modulate the high affinity choline transporter
P Choudhary, EJ Armstrong, CC Jorgensen… - Frontiers in Molecular …, 2017 - frontiersin.org
Cholinergic hypofunction is associated with decreased attention and cognitive deficits in the
central nervous system in addition to compromised motor function. Consequently …
central nervous system in addition to compromised motor function. Consequently …
Nonoisotopic assay for the presynaptic choline transporter reveals capacity for allosteric modulation of choline uptake
AM Ruggiero, J Wright, SM Ferguson… - ACS Chemical …, 2012 - ACS Publications
Current therapies to enhance CNS cholinergic function rely primarily on extracellular
acetylcholinesterase (AChE) inhibition, a pharmacotherapeutic strategy that produces dose …
acetylcholinesterase (AChE) inhibition, a pharmacotherapeutic strategy that produces dose …
Choline
SPH Alexander, A Mathie… - British Journal of …, 2006 - search.proquest.com
S144 Choline Alexander et alCholineOverview: The high-affinity, hemicholinium-3-sensitive,
choline transporter (CHT, provisional nomenclature) is a member of the solute carrier family …
choline transporter (CHT, provisional nomenclature) is a member of the solute carrier family …
Choline transportersbph_505_98 187
CHT Nomenclature, EID ENSG00000115665 - J Neurochem - ncbi.nlm.nih.gov
Overview: The high-affinity, hemicholinium-3-sensitive, choline transporter (CHT, provisional
nomenclature) is a member of the solute carrier family 5 (SLC5) of sodium-dependent …
nomenclature) is a member of the solute carrier family 5 (SLC5) of sodium-dependent …
Transgenic overexpression of the presynaptic choline transporter elevates acetylcholine levels and augments motor endurance
EC Holmstrand, D Lund, AK Cherian, J Wright… - Neurochemistry …, 2014 - Elsevier
Abstract The hemicholinium-3 (HC-3) sensitive, high-affinity choline transporter (CHT)
sustains cholinergic signaling via the presynaptic uptake of choline derived from dietary …
sustains cholinergic signaling via the presynaptic uptake of choline derived from dietary …
The high-affinity choline transporter: a critical protein for sustaining cholinergic signaling as revealed in studies of genetically altered mice
MH Bazalakova, RD Blakely - Neurotransmitter transporters, 2006 - Springer
In cholinergic neurons, the presynaptic choline transporter (CHT) mediates high-affinity
choline uptake (HACU) as the rate-limiting step in acetylcholine (ACh) synthesis. It has …
choline uptake (HACU) as the rate-limiting step in acetylcholine (ACh) synthesis. It has …