Species-Wide Phylogenomics of the Staphylococcus aureus Agr Operon Revealed Convergent Evolution of Frameshift Mutations

V Raghuram, AM Alexander, HQ Loo… - Microbiology …, 2022 - Am Soc Microbiol
Staphylococcus aureus is a prominent nosocomial pathogen that causes several life-
threatening diseases, such as pneumonia and bacteremia. S. aureus modulates the …

Evolution and pathogenesis of Staphylococcus aureus : lessons learned from genotyping and comparative genomics

YE Feng, CJ Chen, LH Su, S Hu, J Yu… - FEMS microbiology …, 2008 - academic.oup.com
Staphylococcus aureus is an opportunistic pathogen and the major causative agent of
numerous hospital-and community-acquired infections. Multilocus sequence typing reveals …

A high-throughput cytotoxicity screening platform reveals agr-independent mutations in bacteraemia-associated Staphylococcus aureus that promote intracellular …

A Hachani, SG Giulieri, R Guérillot, CJ Walsh… - Elife, 2023 - elifesciences.org
Staphylococcus aureus infections are associated with high mortality rates. Often considered
an extracellular pathogen, S. aureus can persist and replicate within host cells, evading …

Genome Plasticity of agr-Defective Staphylococcus aureus during Clinical Infection

DR Altman, MJ Sullivan, KI Chacko… - Infection and …, 2018 - Am Soc Microbiol
Therapy for bacteremia caused by Staphylococcus aureus is often ineffective, even when
treatment conditions are optimal according to experimental protocols. Adapted subclones …

Finding of Agr phase variants in Staphylococcus aureus

V Gor, AJ Takemura, M Nishitani, M Higashide… - Mbio, 2019 - Am Soc Microbiol
Staphylococcus aureus is an important human pathogen whose success is largely attributed
to its vast arsenal of virulence factors that facilitate its invasion into, and survival within, the …

Chemical and Biomolecular Insights into the Staphylococcus aureus Agr Quorum Sensing System: Current Progress and Ongoing Challenges

TJ Polaske, KHJ West, K Zhao… - Israel journal of …, 2023 - Wiley Online Library
Staphylococcus aureus is a ubiquitous bacterium that has become a major threat to human
health due to its extensive toxin production and tremendous capacity for antibiotic resistance …

Cross-Talk between Staphylococcus aureus and Other Staphylococcal Species via the agr Quorum Sensing System

J Canovas, M Baldry, MS Bojer, PS Andersen… - Frontiers in …, 2016 - frontiersin.org
Staphylococci are associated with both humans and animals. While most are non-
pathogenic colonizers, Staphylococcus aureus is an opportunistic pathogen capable of …

Genomic exploration of sequential clinical isolates reveals a distinctive molecular signature of persistent Staphylococcus aureus bacteraemia

SG Giulieri, SL Baines, R Guerillot, T Seemann… - Genome medicine, 2018 - Springer
Background Large-scale genomic studies of within-host diversity in Staphylococcus aureus
bacteraemia (SAB) are needed to understanding bacterial adaptation underlying …

Allele-dependent differences in quorum-sensing dynamics result in variant expression of virulence genes in Staphylococcus aureus

E Geisinger, J Chen, RP Novick - Journal of bacteriology, 2012 - Am Soc Microbiol
Agr is an autoinducing, quorum-sensing system that functions in many Gram-positive
species and is best characterized in the pathogen Staphylococcus aureus, in which it is a …

Niche-specific genome degradation and convergent evolution shaping Staphylococcus aureus adaptation during severe infections

SG Giulieri, R Guérillot, S Duchene, A Hachani… - Elife, 2022 - elifesciences.org
During severe infections, Staphylococcus aureus moves from its colonising sites to blood
and tissues and is exposed to new selective pressures, thus, potentially driving adaptive …