Species-Wide Phylogenomics of the Staphylococcus aureus Agr Operon Revealed Convergent Evolution of Frameshift Mutations
Staphylococcus aureus is a prominent nosocomial pathogen that causes several life-
threatening diseases, such as pneumonia and bacteremia. S. aureus modulates the …
threatening diseases, such as pneumonia and bacteremia. S. aureus modulates the …
Evolution and pathogenesis of Staphylococcus aureus : lessons learned from genotyping and comparative genomics
Staphylococcus aureus is an opportunistic pathogen and the major causative agent of
numerous hospital-and community-acquired infections. Multilocus sequence typing reveals …
numerous hospital-and community-acquired infections. Multilocus sequence typing reveals …
A high-throughput cytotoxicity screening platform reveals agr-independent mutations in bacteraemia-associated Staphylococcus aureus that promote intracellular …
Staphylococcus aureus infections are associated with high mortality rates. Often considered
an extracellular pathogen, S. aureus can persist and replicate within host cells, evading …
an extracellular pathogen, S. aureus can persist and replicate within host cells, evading …
Genome Plasticity of agr-Defective Staphylococcus aureus during Clinical Infection
Therapy for bacteremia caused by Staphylococcus aureus is often ineffective, even when
treatment conditions are optimal according to experimental protocols. Adapted subclones …
treatment conditions are optimal according to experimental protocols. Adapted subclones …
Finding of Agr phase variants in Staphylococcus aureus
V Gor, AJ Takemura, M Nishitani, M Higashide… - Mbio, 2019 - Am Soc Microbiol
Staphylococcus aureus is an important human pathogen whose success is largely attributed
to its vast arsenal of virulence factors that facilitate its invasion into, and survival within, the …
to its vast arsenal of virulence factors that facilitate its invasion into, and survival within, the …
Chemical and Biomolecular Insights into the Staphylococcus aureus Agr Quorum Sensing System: Current Progress and Ongoing Challenges
TJ Polaske, KHJ West, K Zhao… - Israel journal of …, 2023 - Wiley Online Library
Staphylococcus aureus is a ubiquitous bacterium that has become a major threat to human
health due to its extensive toxin production and tremendous capacity for antibiotic resistance …
health due to its extensive toxin production and tremendous capacity for antibiotic resistance …
Cross-Talk between Staphylococcus aureus and Other Staphylococcal Species via the agr Quorum Sensing System
J Canovas, M Baldry, MS Bojer, PS Andersen… - Frontiers in …, 2016 - frontiersin.org
Staphylococci are associated with both humans and animals. While most are non-
pathogenic colonizers, Staphylococcus aureus is an opportunistic pathogen capable of …
pathogenic colonizers, Staphylococcus aureus is an opportunistic pathogen capable of …
Genomic exploration of sequential clinical isolates reveals a distinctive molecular signature of persistent Staphylococcus aureus bacteraemia
Background Large-scale genomic studies of within-host diversity in Staphylococcus aureus
bacteraemia (SAB) are needed to understanding bacterial adaptation underlying …
bacteraemia (SAB) are needed to understanding bacterial adaptation underlying …
Allele-dependent differences in quorum-sensing dynamics result in variant expression of virulence genes in Staphylococcus aureus
E Geisinger, J Chen, RP Novick - Journal of bacteriology, 2012 - Am Soc Microbiol
Agr is an autoinducing, quorum-sensing system that functions in many Gram-positive
species and is best characterized in the pathogen Staphylococcus aureus, in which it is a …
species and is best characterized in the pathogen Staphylococcus aureus, in which it is a …
Niche-specific genome degradation and convergent evolution shaping Staphylococcus aureus adaptation during severe infections
During severe infections, Staphylococcus aureus moves from its colonising sites to blood
and tissues and is exposed to new selective pressures, thus, potentially driving adaptive …
and tissues and is exposed to new selective pressures, thus, potentially driving adaptive …