More than 50 years ago, John West and colleagues (1) published their landmark study on
the vertical distribution of blood flow in the lung as a result of the interplay between the local …

Despite the importance of dynamic changes in the regional distributions of gas and blood
during the breathing cycle for lung function in the mechanically ventilated patient, no …

Early in the last century, JS Haldane observed,“It is probable indeed that in some way or
other the air supply is proportioned to the blood supply, whether by regulation through the …

Rationale: Regional lung function depends on the amount of capillary blood that interfaces
with alveolar air, and both parameters dynamically change during the respiratory cycle …

It is an exciting time for pulmonary medicine. Genetic and molecular techniques are
providing deeper insight into disease mechanisms. As a consequence, diseases are …

In vivo imaging is an important tool for preclinical studies of lung function and disease. The
widespread availability of multimodal animal imaging systems and the rapid rate of …

The pulmonary circulation carries deoxygenated blood from the systemic veins through the
pulmonary arteries to be oxygenated in the capillaries that line the walls of the pulmonary …

The role of imaging as a tool for investigating lung physiology is growing at an accelerating
pace. Looking forward, we wished to identify unresolved issues in lung physiology that might …

Lungs play the most important role in the gas exchange process by transferring oxygen from
the inhaled air to blood. Any chronic pulmonary abnormality eventually causes …

Lungs represent the essential part of the mammalian respiratory system, which is reflected in
the fact that lung failure still is one of the leading causes of morbidity and mortality …