Can women's health botanicals prevent estrogen carcinogenesis?

BM Dietz, TL Dunlap, A Hajirahimkhan, S Wang… - Planta …, 2015 - thieme-connect.com
Breast cancer is the second most common malignancy among women becoming even more
prevalent with age. Three major pathways are considered to be important in estrogen …

Modulation of estrogen chemical carcinogenesis by botanical supplements used for postmenopausal women's health

CS Snelten, B Dietz, JL Bolton - Drug Discovery Today: Disease …, 2012 - Elsevier
Breast cancer risk has been associated with long-term estrogen exposure including
traditional hormone therapy (HT, formally hormone replacement therapy). To avoid …

Abstract PS8-10: Inhibition of estrogen biosynthesis by hops, licorice species, and their bioactive compounds

A Hajirahimkhan, C Howell, T Dunlap, SN Chen… - Cancer Research, 2021 - AACR
Introduction: Breast cancer risk continues to rise following menopause, despite the cessation
of ovarian estrogen synthesis. Pathways involving increased aromatase activity and …

Modulation of Estrogenic Activity in Estrogen Receptor α and β by Flavonoids in Women's Health Botanicals

OC Mbachu - 2019 - search.proquest.com
Menopausal women have been choosing natural alternatives over conventional hormone
treatments to manage their symptoms, partly due to a reported increase in risk of breast …

Modulation of Estrogen Oxidative Metabolism by Botanicals (Hops and Licorice) Used for Women's Health

S Wang - 2017 - indigo.uic.edu
Estrogen is the primary hormone in women that plays an important role in maintaining
normal functions of various tissues and organs. However, elongated exposure to estrogen …

The Role of Botanicals and Their AhR-Active Compounds in Estrogen Chemical Carcinogenesis

RT Hitzman - 2021 - search.proquest.com
Botanical dietary supplements (BDS) are increasingly popular and may provide resilience in
women. Women's health BDS were initially evaluated for an ability to influence the estrogen …

The Role of Estradiol in the Modulation of Estrogen Chemical Carcinogenesis by Isoflavones

CE Howell - 2019 - search.proquest.com
Abstract Since the Women's Health Initiative reported that hormone therapy correlated with
increased risk of breast cancer, many women have turned to botanical dietary supplements …

Evidence for Chemopreventive and Resilience Activity of Licorice: Glycyrrhiza Glabra and G. Inflata Extracts Modulate Estrogen Metabolism in ACI Rats

S Wang, TL Dunlap, L Huang, Y Liu, C Simmler… - Cancer Prevention …, 2018 - AACR
Women are increasingly using botanical dietary supplements (BDS) to reduce menopausal
hot flashes. Although licorice (Glycyrrhiza sp.) is one of the frequently used ingredients in …

Berries and ellagic acid prevent estrogen-induced mammary tumorigenesis by modulating enzymes of estrogen metabolism

HS Aiyer, RC Gupta - Cancer prevention research, 2010 - AACR
To determine whether dietary berries and ellagic acid prevent 17β-estradiol (E2)–induced
mammary tumors by altering estrogen metabolism, we randomized August-Copenhagen …

Hops (Humulus lupulus) Inhibits Oxidative Estrogen Metabolism and Estrogen-Induced Malignant Transformation in Human Mammary Epithelial cells (MCF-10A)

LP Hemachandra, P Madhubhani… - Cancer prevention …, 2012 - AACR
Long-term exposure to estrogens including those in traditional hormone replacement
therapy (HRT) increases the risk of developing hormone-dependent cancers. As a result …