Guardian of Excitability: Multifaceted Role of Galanin in Whole Brain Excitability

NN Rieser, M Ronchetti, AL Hotz, SCF Neuhauss - bioRxiv, 2024 - biorxiv.org
Galanin is a neuropeptide, which is critically involved in homeostatic processes like
controlling arousal, sleep, and regulation of stress. This extensive range of functions aligns …

Neuroanatomical localization of galanin in zebrafish telencephalon and anticonvulsant effect of galanin overexpression

P Podlasz, A Jakimiuk, N Kasica-Jarosz… - ACS chemical …, 2018 - ACS Publications
Galanin is a neuropeptide widely expressed in the nervous system, but it is also present in
non-neuronal locations. In the brain, galanin may function as an inhibitory neurotransmitter …

Galanin and galanin receptors in epilepsy

AM Mazarati - Neuropeptides, 2004 - Elsevier
The shift in the balance between the inhibition and the excitation in favor of the latter is a
major mechanism of the evolvement of epileptic seizures. On the neurotransmitter level two …

[HTML][HTML] Galanin receptor 1 deletion exacerbates hippocampal neuronal loss after systemic kainate administration in mice

PE Schauwecker - PLoS One, 2010 - journals.plos.org
Background Galanin is a neuropeptide with a wide distribution in the central and peripheral
nervous systems and whose physiological effects are mediated through three G protein …

Galanin receptor-1 knockout mice exhibit spontaneous epilepsy, abnormal EEGs and altered inhibition in the hippocampus

CD McColl, AS Jacoby, J Shine, TP Iismaa… - …, 2006 - Elsevier
Galanin is a widely-distributed neuropeptide that acts as an endogenous anticonvulsant. We
have recently generated a galanin receptor type 1 knockout mouse (Galr1−/−) that develops …

Modulation of hippocampal excitability and seizures by galanin

AM Mazarati, JG Hohmann, A Bacon, H Liu… - Journal of …, 2000 - Soc Neuroscience
Previous studies have shown that the expression of the neuropeptide galanin in the
hippocampus is altered by seizures and that exogenous administration of galanin into the …

Galanin Receptors Modulate Seizures: Galanin Receptors Modulate Seizures

J Kapur - Epilepsy Currents, 2011 - journals.sagepub.com
BACKGROUND: Galanin is a neuropeptide with a wide distribution in the central and
peripheral nervous systems and whose physiological effects are mediated through three G …

Elimination of galanin synthesis in noradrenergic neurons reduces galanin in select brain areas and promotes active coping behaviors

RP Tillage, NR Sciolino, NW Plummer… - Brain Structure and …, 2020 - Springer
Accumulating evidence indicates that disruption of galanin signaling is associated with
neuropsychiatric disease, but the precise functions of this neuropeptide remain largely …

Galanin: a novel therapeutic target for depression, anxiety disorders and drug addiction?

A Holmes, MR Picciotto - CNS & Neurological Disorders-Drug …, 2006 - ingentaconnect.com
Galanin is a neuropeptide synthesized in many neuronal types including brainstem
norepinephrine-producing cells of the locus coeruleus and the serotonin-producing neurons …

Effects of galanin on monoaminergic systems and HPA axis: Potential mechanisms underlying the effects of galanin on addiction-and stress-related behaviors

MR Picciotto, C Brabant, EB Einstein, HM Kamens… - Brain research, 2010 - Elsevier
Like a number of neuropeptides, galanin can alter neural activity in brain areas that are
important for both stress-related behaviors and responses to drugs of abuse. Accordingly …