Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide. Considerable
efforts are needed to elucidate the underlying mechanisms for the prevention and treatment …

Atherosclerosis is a complex inflammatory disease involving extensive vascular vessel
remodelling and migration of vascular cells. As RCAN1 is implicated in cell migration, we …

Abstract Regulator of calcineurin 3 (RCAN3) belongs to the human RCAN gene family,
which also includes RCAN1 and RCAN2. All three members interact with and inhibit …

Atherosclerosis, one of the main causes of cardiovascular diseases, is a complex process
that involves manifold factors. Besides the vascular lipids accumulation, inflammatory factors …

RCAN1 (Adapt78) functions mainly, if not exclusively, as a regulator of calcineurin, a
phosphatase that mediates many cellular responses to calcium. Identification of this …

Artery wall remodeling, a major feature of diseases such as hypertension, restenosis,
atherosclerosis, and aneurysm, involves changes in the tunica media mass that reduce or …

Atherosclerosis is one of the most common vascular disorders. Endothelial cell (EC)
dysfunction and vascular smooth muscle cell (VSMC) proliferation contributes to the …

Corbalan and Kitsis RCAN1, Mitochondrial Dynamics, and Cell Death 797 membrane
(Δψm)—a driving force in the movement of Ca2+ into the mitochondrial matrix through the …

Abstract Regulator of calcineurin 1 (RCAN1) is an endogenous inhibitor of the calcineurin
pathway in cells. It is expressed as two isoforms in vertebrates: RCAN1. 1 is constitutively …

Objective Cardiac dysfunction and remodeling are serious complications of sepsis and are
the main causes of death in sepsis. RCAN1 is a feedback regulator of cardiac hypertrophy …