Kisspeptin is vital for the neuroendocrine regulation of GNRH secretion. Kisspeptin neurons
are now recognized as a central pathway responsible for conveying key homeostatic …

Kisspeptin is vital for the neuroendocrine regulation of GNRH secretion. Kisspeptin neurons
are now recognized as a central pathway responsible for conveying key homeostatic …

Body energy balance and metabolic signals are important modulators of puberty and
reproductive function, so that perturbations of metabolism and energy reserves (ranging …

Hypothalamic kisspeptin neurons serve as the nodal regulatory centre of reproductive
function. These neurons are subjected to a plethora of regulatory factors that ultimately affect …

Kisspeptin is a neuropeptide with a critical role in the function of the hypothalamic–pituitary–
gonadal (HPG) axis. Kisspeptin is produced by two major populations of neurons located in …

Body energy reserves and metabolic state are relevant modifiers of puberty onset and
fertility; forms of metabolic stress ranging from persistent energy insufficiency to morbid …

Hypothalamic kisspeptin (Kiss1) neurons provide indispensable excitatory transmission to
gonadotropin-releasing hormone (GnRH) neurons for the coordinated release of …

Kisspeptin has recently been identified as a key neuroendocrine gatekeeper of reproduction
and is essential for the initiation of human puberty and maintenance of adult reproduction …

Kisspeptin (encoded by the Kiss1 gene) and its receptor, KISS1R (encoded by the Kiss1r
gene), have well-established roles in stimulating reproduction via central actions on …

Hypothalamic control of fertility is the quintessential homeostatic function. However, fertility is
metabolically demanding; so, there must be coordination between energy states and …