[HTML][HTML] Specificity and reproducibility of nasal biomarkers in patients with allergic rhinitis after allergen challenge chamber exposure

P Badorrek, M Müller, W Koch, JM Hohlfeld… - Annals of Allergy, Asthma …, 2017 - Elsevier
Background Allergic rhinitis is an inflammatory disease that causes cellular influx and
mediator release in the nose. These inflammatory changes might be used as nasal …

Optimisation of grass pollen nasal allergen challenge for assessment of clinical and immunological outcomes

GW Scadding, MA Calderon, V Bellido, GK Koed… - Journal of …, 2012 - Elsevier
Nasal allergen challenge can be used to assess the clinical and immunological aspects of
rhinitis due to inhalant allergens. We aimed to develop a reproducible technique for grass …

Effector cell signature in peripheral blood following nasal allergen challenge in grass pollen allergic individuals

MH Shamji, V Bellido, GW Scadding, JA Layhadi… - Allergy, 2015 - Wiley Online Library
Background Several studies have demonstrated the time course of inflammatory mediators
in nasal fluids following nasal allergen challenge (NAC), whereas the effects of NAC on cells …

Comparative responses to nasal allergen challenge in allergic rhinitic subjects with or without asthma

MC Rousseau, ME Boulay, L Goronfolah… - Allergy, Asthma & …, 2011 - Springer
Background Nasal allergen challenge (NAC) is useful to study the pathophysiology of
rhinitis, and multiple challenges may more adequately approximate natural exposure …

Safety and reproducibility of nasal allergen challenge

I Eguiluz‐Gracia, A Testera‐Montes, M González… - Allergy, 2019 - Wiley Online Library
Background The nasal allergen challenge (NAC) is a useful tool for the diagnosis of allergic
rhinitis (AR) and local allergic rhinitis (LAR) and might serve to design and monitor allergen …

[PDF][PDF] Applicability and reproducibility of biomarkers for the evaluation of anti-inflammatory therapy in allergic rhinitis

JD Boot, P Chandoesing, ML De Kam… - J Investig Allergol …, 2008 - researchgate.net
■ Abstract Background: We aimed to study the reproducibility of several biomarkers of
allergic rhinitis to investigate their potential as outcome measures in clinical intervention …

Diagnostic value of outcome measures following allergen exposure in an environmental challenge chamber compared with natural conditions

JM Hohlfeld, T Holland‐Letz, M Larbig… - Clinical & …, 2010 - Wiley Online Library
Background Efficacy testing of drugs in seasonal allergic rhinitis (SAR) is often disturbed by
seasonal variations of environmental allergens, and assessment of onset and duration of …

Nasal allergen challenge studies of allergic rhinitis: a guide for the practicing clinician

M Soliman, ML North, LM Steacy, J Thiele… - Annals of Allergy …, 2014 - annallergy.org
Review the target audience, learning objectives and all disclosures. Complete the pre-test
online at http://www. annallergy. org (click on the CME heading). Follow the online …

The time course of the bilateral release of cytokines and mediators after unilateral nasal allergen challenge

M Wagenmann, L Schumacher, C Bachert - Allergy, 2005 - Wiley Online Library
Background: Late phase reactions after allergen challenge can be understood as a correlate
of the inflammatory reaction in allergic rhinitis. Methods: To investigate which cytokines are …

Nasal allergen challenge (NAC): Practical aspects and applications from an EU/US perspective—a Work Group Report of the AAAAI Rhinitis, Rhinosinusitis and …

SH Cho, A Nanda, A Keswani, A Adinoff… - Journal of Allergy and …, 2023 - Elsevier
Nasal allergen challenge (NAC) is applied in a variety of settings (research centers,
specialty clinics, and hospitals) as a useful diagnostic and research tool. NAC is indicated …