Receiving a kidney transplant currently requires patients to commit to life-long
immunosuppression therapy. The combination of immunosuppressive drugs currently taken …

The induction of graft tolerance remains the holy grail of transplantation. This is important as
chronic allograft dysfunction and the side effects of immunosuppression regimens place a …

Over the past few years, the therapeutic potential of Treg has been highlighted in the field of
autoimmune diseases and after allogeneic transplantation. The first hurdle for the …

Regulatory T cell (Treg)-based therapeutics are receiving increased attention for their
potential to treat autoimmune disease and prevent transplant rejection. Adoptively …

The contribution of regulatory T cells (Treg) to the induction and maintenance of tolerance is
well-recognized in rodents and may contribute to long-term human organ allograft survival …

Regulatory T cell (Treg)-based immunotherapy is of great interest to induce tolerance in
clinical transplantation settings. In fact, the first clinical trials of Treg infusion after stem cell …

Apart from clonal deletion of self-reactive T cells in the thymus, Tregs are the major
regulators of immune responses in the periphery and maintain a state of self-tolerance free …

Interest in adoptive T-cell therapies has been ignited by the recent clinical success of
genetically-modified T cells in the cancer immunotherapy space. In addition to immune …

Regulatory T cells (Tregs) are essential to transplantation tolerance and their therapeutic
efficacy is well documented in animal models. Moreover, human Tregs can be identified …

Modern immunosuppression regimens effectively control acute rejection and decrease graft
loss in the first year after transplantation; however, these regimens do not have a durable …