Affinity-enhanced multimeric VEGF (vascular endothelial growth factor) and PlGF (placental growth factor) variants for specific adsorption of sFlt-1 to restore …

M Matin, M Mörgelin, J Stetefeld, B Schermer… - …, 2020 - Am Heart Assoc
Preeclampsia is a potentially life-threatening multisystem disease affecting 4% to 8% of
pregnant women after the 20th week of gestation. An excess of placental expressed …

VEGF (vascular endothelial growth factor) functionalized magnetic beads in a microfluidic device to improve the angiogenic balance in preeclampsia

L Trapiella-Alfonso, L Alexandre, C Fraichard… - …, 2019 - Am Heart Assoc
Preeclampsia is a hypertensive pregnancy disease associated with a massive increase in
sFlt-1 (soluble form of the vascular endothelial growth factor 1) in the maternal circulation …

A Maternally Sequestered, Biopolymer‐Stabilized Vascular Endothelial Growth Factor (VEGF) Chimera for Treatment of Preeclampsia

OC Logue, F Mahdi, H Chapman… - Journal of the …, 2017 - Am Heart Assoc
Background Preeclampsia is a hypertensive syndrome that complicates 3% to 5% of
pregnancies in the United States. Preeclampsia originates from an improperly vascularized …

Pilot study of extracorporeal removal of soluble fms-like tyrosine kinase 1 in preeclampsia

R Thadhani, T Kisner, H Hagmann, V Bossung… - Circulation, 2011 - Am Heart Assoc
Background—Targeted therapies to stabilize the clinical manifestations and prolong
pregnancy in preeclampsia do not exist. Soluble fms-like tyrosine kinase 1 (sFlt-1), an …

Elastin-like polypeptide: VEGF-B fusion protein for treatment of preeclampsia

JP Waller, JA Howell, H Peterson, EM George… - …, 2021 - Am Heart Assoc
Preeclampsia is characterized by the development of elevated blood pressure during the
second and third trimesters of pregnancy that is accompanied by end organ dysfunction. The …

Magnetic blood purification‐based soluble fms‐like tyrosine kinase‐1 removal in comparison with dextran sulfate apheresis and therapeutic plasma exchange

T Rduch, N Arn, J Kinkel, T Fischer, I Binet… - Artificial …, 2023 - Wiley Online Library
Background Preeclampsia remains one of the most serious complications of pregnancy.
Effective therapies are yet to be developed. Recent research has identified an imbalance of …

[HTML][HTML] Pathogenesis of preeclampsia and therapeutic approaches targeting the placenta

MK Jena, NR Sharma, M Petitt, D Maulik, NR Nayak - Biomolecules, 2020 - mdpi.com
Preeclampsia (PE) is a serious pregnancy complication, affecting about 5–7% of
pregnancies worldwide and is characterized by hypertension and damage to multiple …

Assessing the circulating placental-specific anti-angiogenic protein sFLT-1 e15a in preeclampsia

K Palmer - Preeclampsia: Methods and Protocols, 2018 - Springer
Preeclampsia is a common obstetric complication globally responsible for a significant
burden of maternal and perinatal morbidity and mortality. The anti-angiogenic protein, sFLT …

[HTML][HTML] Pro-angiogenic therapeutics for preeclampsia

AC Eddy, GL Bidwell III, EM George - Biology of sex differences, 2018 - Springer
Preeclampsia is a pregnancy-induced hypertensive disorder resulting from abnormal
placentation, which causes factors such as sFlt-1 to be released into the maternal …

Case of soluble fms‐like tyrosine kinase 1 apheresis in severe pre‐eclampsia developed at 15 weeks' gestation

B Nakakita, H Mogami, E Kondoh… - Journal of Obstetrics …, 2015 - Wiley Online Library
Soluble fms‐like tyrosine kinase‐1 (sFlt1), a circulating vascular endothelial growth factor
receptor 1 antagonist, is associated with the pathogenesis of pre‐eclampsia. Extracorporeal …