Phenytoin has a widespread use in epilepsy treatment and is mainly metabolized by hepatic
cytochrome P450 enzymes (CYP). We have investigated CYP2C9* 2, CYP2C9* 3 …

The objective of this study was to study the effect of CYP2C9 genetic polymorphism and
undernourishment on free phenytoin concentrations in epileptic patients. The study was …

Phenytoin (PHT) is an antiepileptic drug widely used in the treatment of focal epilepsy and
status epilepticus, and effective in controlling focal seizures with and without tonic–clonic …

We examined the contribution of CYP2C9 and CYP2C19 genotypes and drug interactions to
the phenytoin metabolism among 97 Korean epileptic patients to determine if …

To search for the optimal dosage of phenytoin in patients with epilepsy based on the
metabolic activities of CYP2C9 and CYP2C19 polymorphisms, a total of 169 patients …

Purpose: The aim of this study was to clarify the effects of genetic polymorphisms of
cytochrome P450 (CYP) 2C9 and 2C19 on the metabolism of phenytoin (PHT). In addition, a …

Objective To examine the genetic polymorphism of CYP2C9 and CYP2C19 and its effect on
the pharmacokinetics of phenytoin among 44 Japanese patients with epilepsy. Methods …

Objective To investigate the relationship between the genetic polymorphism of cytochrome
CYP2C19 and CYP2C9 and the serum concentration of phenytoin (PHT) in patients with …

Background: Genetic polymorphisms of CYP2C9 can lead to wide inter-individual variations
in drug metabolism. Decreased metabolism leads to higher plasma levels, causing adverse …

Abstract Objective Cytochrome P450 2C9 and 2C19 (CYP2C9 and CYP2C19, respectively)
genetic polymorphisms play an important role in phenytoin (PHT) metabolism. We have …