BACKGROUND Endocrine therapy for prostate cancer aims to reduce the levels of
circulating androgen or to inhibit androgen action by blocking the androgen receptor in the …

The last decade has brought increased awareness to prostate cancer as a significant health
problem. Prostate cancer is very heterogeneous in its etiology and progression, but …

The androgen receptor plays a pivotal role in the prostate. Its primary function is to provide
responsive gene products for differentiation and growth, but under abnormal conditions it …

Androgen blockade is the mainstay of therapy in the clinical management of advanced
prostate cancer. Recent progress on two fronts–the development of newer xenograft and …

Prostate cancer is a significant cause of morbidity and mortality worldwide. Normal prostate
tissue is regulated by androgens, which activate the androgen receptor, a nuclear receptor …

Advanced prostate tumors, which are androgen dependent, are often initially treated in the
clinic with hormone ablation therapy, either through surgical castration or administration of …

INTRODUCTION In many developed countries, prostate cancer is the most common
malignancy in men. When localized, the cancer is curable by radical prostatectomy or …

Simple Summary Prostate cancer is the second most common cancer in men world-wide,
with nearly 1.3 million new cases each year, and over the next twenty years the incidence …

Androgen receptor (AR) is known to be overexpressed in castration-resistant prostate
cancer. To interrogate the functional significance of the AR level, we established two LNCaP …

Androgen receptor (AR), a key nuclear transcription factor in the prostate gland, is
expressed in all histological types and stages of prostate cancer. The AR regulates …