Recent studies have highlighted the involvement of the kynurenine pathway in the pathology
of neurodegenerative diseases, but the role of this system in neuropathic pain requires …

Neuropathic pain caused by a primary injury or dysfunction in the peripheral or central
nervous system is a tremendous therapeutic challenge. Here, we have collected the first …

Pain and depression often co-occur, but the underlying mechanisms have not been
elucidated. Here, we used the spared nerve injury (SNI) model in mice to induce both …

Chronic stress or inflammation increases tryptophan metabolism along the kynurenine
pathway (KP), and the generation of neuroactive kynurenine metabolites contributes to …

Kynurenine 3-mono-oxygenase, one of the key enzymes of the “kynurenine pathway”,
catalyses the formation of 3-hydroxykynurenine and may direct the neo-synthesis of …

Neuropathic pain is one of the most important clinical consequences of injury to the
somatosensory system. Nevertheless, the critical pathophysiological mechanisms involved …

It is important to understand the involvement of oligodendrocytes in the kynurenine pathway
(KP) and more particularly, their potential ability to produce neuroprotective metabolites …

Upregulation of the kynurenine pathway (KP) of tryptophan metabolism is commonly
observed in neurodegenerative disease. When activated, L-kynurenine (KYN) increases in …

J. Neurochem.(2011) 118, 816–825. Abstract Amyotrophic lateral sclerosis (ALS) is the most
common type of motor neuron degenerative disease for which the aetiology is still unknown …

Kynurenine 3-monooxygenase (KMO), a key player in the kynurenine pathway (KP) of
tryptophan degradation, regulates the synthesis of the neuroactive metabolites 3 …