Neuroprotective effect of treatment with human albumin in permanent focal cerebral ischemia: histopathology and cortical perfusion studies

Y Liu, L Belayev, W Zhao, R Busto, A Belayev… - European journal of …, 2001 - Elsevier
In recent experimental studies, we demonstrated a highly beneficial neuroprotective effect of
moderate-to high-dose human albumin treatment of transient focal cerebral ischemia, but we …

[HTML][HTML] The effect of high-dose albumin therapy on local cerebral perfusion after transient focal cerebral ischemia in rats

PW Huh, L Belayev, W Zhao, R Busto, I Saul… - Brain research, 1998 - Elsevier
We have shown that high-concentration albumin therapy is markedly neuroprotective in
focal cerebral ischemia. The present study was conducted to ascertain the degree to which …

Human albumin therapy of acute ischemic stroke: marked neuroprotective efficacy at moderate doses and with a broad therapeutic window

L Belayev, Y Liu, W Zhao, R Busto, MD Ginsberg - Stroke, 2001 - Am Heart Assoc
Background and Purpose—We examined the neuroprotective efficacy of moderate-dose
human albumin therapy in acute focal ischemic stroke and defined the therapeutic window …

Albumin therapy in acute stroke patients

DH Shin, GJ Moon, OY Bang - Journal of neurology, 2007 - Springer
Preclinical studies have recently shown that albumin has neuroprotective effects for stroke in
animal models. Thus, we sought to evaluate the effects of albumin therapy in patients with …

[HTML][HTML] Protein extravasation and cellular uptake after high-dose human-albumin treatment of transient focal cerebral ischemia in rats

M Remmers, R Schmidt-Kastner, L Belayev, B Lin… - Brain research, 1999 - Elsevier
Treatment with human albumin administered intravenously in the immediate post-ischemic
period following a 2-h period of transient focal cerebral ischemia leads to a reduction of …

[HTML][HTML] Neuroprotective effect of high-dose albumin therapy against global ischemic brain injury in rats

L Belayev, I Saul, PW Huh, N Finotti, W Zhao, R Busto… - Brain research, 1999 - Elsevier
The purpose of this study was to determine whether treatment with high-dose human serum
albumin (HSA) would offer protection in a model of high-grade transient forebrain ischemia …

Albumin therapy of transient focal cerebral ischemia: in vivo analysis of dynamic microvascular responses

L Belayev, E Pinard, H Nallet, J Seylaz, Y Liu… - Stroke, 2002 - Am Heart Assoc
Background and Purpose—To study whether intravascular or hemodynamic factors
contribute to the marked neuroprotective effect of albumin therapy in focal cerebral ischemia …

[HTML][HTML] Repeated oral administration of human serum albumin protects from the cerebral ischemia in rat brain following MCAO

H Park, M Hong, GJ Jhon, Y Lee… - Experimental …, 2017 - ncbi.nlm.nih.gov
Albumin is known to have neuroprotective effects. The protein has a long half-life circulation,
and its effects can therefore persist for a long time to aid in the recovery of brain ischemia. In …

Diffusion-weighted magnetic resonance imaging confirms marked neuroprotective efficacy of albumin therapy in focal cerebral ischemia

L Belayev, W Zhao, PM Pattany, RG Weaver, PW Huh… - Stroke, 1998 - Am Heart Assoc
Background and Purpose—We have recently shown high-dose human serum albumin
therapy to confer marked histological protection in experimental middle cerebral artery …

Effect of delayed albumin hemodilution on infarction volume and brain edema after transient middle cerebral artery occlusion in rats

L Belayev, R Busto, W Zhao, JA Clemens… - Journal of …, 1997 - thejns.org
✓ The authors examined the effect of delayed high-concentration albumin therapy on
ischemic injury in a highly reproducible model of middle cerebral artery (MCA) occlusion in …