An essential aspect of normal brain function is the bidirectional interaction and
communication between neurons and neighbouring glial cells. To this end, the brain has …

Fractalkine (FKN, CX3CL1) is a transmembrane chemokine expressed by neurons in the
central nervous system (CNS). CX3CL1 signals through its unique receptor, CX3CR1, that is …

Microglial cells are the resident macrophages of the central nervous system (CNS). Besides
their classical roles in pathological conditions, these immune cells also dynamically interact …

Microglial cells participate in brain development and influence neuronal loss and synaptic
maturation. Fractalkine is an important neuronal chemokine whose expression increases …

Neural circuits are constantly monitored and supported by the surrounding microglial cells,
using finely tuned mechanisms which include both direct contact and release of soluble …

Abstract Background Fractalkine (CX3CL1; FKN) is a chemokine expressed by neurons that
mediates communication between neurons and microglia. By regulating microglial activity …

Neuroinflammation was initially thought of as a consequence of neurodegenerative disease
pathology, but more recently it is becoming clear that it plays a significant role in the …

Alzheimer's disease (AD) is a progressive, neurodegenerative disorder, and the most
common form of dementia. As the understanding of AD has progressed, it is now believed …

The development of new therapeutic approaches to the treatment of painful neuropathies
requires a better understanding of the mechanisms that underlie chronic pain syndromes …

In the CNS, the chemokine CX3CL1 (fractalkine) is expressed on neurons while its specific
receptor CX3CR1 is expressed on microglia and macrophages. Microglia play an important …