Background Bronchodilator responsiveness is a potential phenotypic characteristic of
chronic obstructive pulmonary disease (COPD). We studied whether change in lung function …

Background: A limited or absent bronchodilator response is used to classify chronic
obstructive pulmonary disease (COPD) and can determine the treatment offered. The …

Rationale: Although the rate of annual decline in FEV1 is one of the most important outcome
measures in chronic obstructive pulmonary disease (COPD), little is known about …

Background Interactions between spirometry and patient-reported outcomes in COPD are
not well understood. This systematic review and study-level analysis investigated the …

Background In clinical trials of inhaled bronchodilators, chronic obstructive pulmonary
disease (COPD) guidelines recommend that patient-reported outcomes (PROs) are …

Rationale: Whether pharmacological therapy alters decline in FEV1 in chronic obstructive
pulmonary disease remains controversial. Because pharmacotherapy improves health …

Background Debate continues as to whether acute bronchodilator responsiveness (BDR)
predicts long-term outcomes in COPD. Furthermore, there is no consensus on a threshold …

Rationale: The American Thoracic Society (ATS)/European Respiratory Society defines a
positive bronchodilator response (BDR) by a composite of BDR in either forced expiratory …

Bronchodilator response (BDR) testing is used as a diagnostic method in obstructive airway
diseases. The aim of this investigation was to compare different methods for measuring BDR …

Partial bronchodilator reversibility can be demonstrated in many patients with stable chronic
obstructive pulmonary disease (COPD), but its relevance to exercise capacity and symptoms …