Calcium (Ca2+) plays many important regulatory roles in cardiac muscle cells. In the initial
phase of the action potential, influx of Ca2+ through sarcolemmal voltage‐gated L‐type …

Cardiomyocyte calcium-handling is the key mediator of cardiac excitation-contraction
coupling. In the healthy heart, calcium controls both electrical impulse propagation and …

Excitation–contraction coupling in the cardiac myocyte is mediated by a number of highly
integrated mechanisms of intracellular Ca2+ transport. The complexity and integrative …

Excitation–contraction coupling describes the processes relating to electrical excitation
through force generation and contraction in the heart. It occurs at multiple levels from the …

Abstract Calcium (Ca 2+) plays a central role in cardiomyocyte excitation-contraction
coupling. To ensure an optimal electrical impulse propagation and cardiac contraction, Ca …

Excitation–contraction coupling in cardiac myocytes requires calcium influx through L-type
calcium channels in the sarcolemma, which gates calcium release through sarcoplasmic …

Mathematical and computational modeling of cardiac excitation–contraction coupling has
produced considerable insights into how the heart muscle contracts. With the increase in …

Calcium (Ca) is a universal intracellular second messenger. In muscle, Ca is best known for
its role in contractile activation. However, in recent years the critical role of Ca in other …

Calcium (Ca2+) is a critical regulator of cardiac myocyte function. Principally, Ca2+ is the
link between the electrical signals that pervade the heart and contraction of the myocytes to …

The heart adapts the rate of mitochondrial ATP production to energy demand without
noticeable changes in the concentration of ATP, ADP and Pi, even for large transitions …