In vivo lung morphometry with accelerated hyperpolarized 3He diffusion MRI: A preliminary study

YV Chang, JD Quirk… - Magnetic resonance in …, 2015 - Wiley Online Library
Purpose Parallel imaging can be used to reduce imaging time and to increase the spatial
coverage in hyperpolarized gas magnetic resonance imaging of the lung. In this proof‐of …

Probing lung microstructure with hyperpolarized 3He gradient echo MRI

AL Sukstanskii, JD Quirk, DA Yablonskiy - NMR in Biomedicine, 2014 - Wiley Online Library
In this paper we demonstrate that gradient echo MRI with hyperpolarized 3He gas can be
used for simultaneously extracting in vivo information about lung ventilation properties …

Rapid hyperpolarized 3He diffusion MRI of healthy and emphysematous human lungs using an optimized interleaved‐spiral pulse sequence

M Salerno, TA Altes, JR Brookeman… - Journal of Magnetic …, 2003 - Wiley Online Library
Purpose To develop and validate an interleaved‐spiral diffusion pulse sequence capable of
hyperpolarized 3He MR imaging of the whole lung in less than 10 seconds. Materials and …

Diffusion lung imaging with hyperpolarized gas MRI

DA Yablonskiy, AL Sukstanskii, JD Quirk - NMR in Biomedicine, 2017 - Wiley Online Library
Lung imaging using conventional 1H MRI presents great challenges because of the low
density of lung tissue, lung motion and very fast lung tissue transverse relaxation (typical T2 …

Imaging lung microstructure in mice with hyperpolarized 3He diffusion MRI

W Wang, NM Nguyen, DA Yablonskiy… - Magnetic resonance …, 2011 - Wiley Online Library
Quantitative measurement of lung microstructure is of great significance in assessment of
pulmonary disease, particularly in the earliest stages. The technique for MRI‐based 3He …

Probing lung microstructure with hyperpolarized noble gas diffusion MRI: theoretical models and experimental results

DA Yablonskiy, AL Sukstanskii, JD Quirk… - Magnetic resonance …, 2014 - Wiley Online Library
The introduction of hyperpolarized gases (3He and 129Xe) has opened the door to
applications for which gaseous agents are uniquely suited—lung MRI. One of the pulmonary …

Whole lung morphometry with 3D multiple b‐value hyperpolarized gas MRI and compressed sensing

HF Chan, NJ Stewart, J Parra‐Robles… - Magnetic resonance …, 2017 - Wiley Online Library
Purpose To demonstrate three‐dimensional (3D) multiple b‐value diffusion‐weighted (DW)
MRI of hyperpolarized 3He gas for whole lung morphometry with compressed sensing (CS) …

q‐space analysis of lung morphometry in vivo with hyperpolarized 3He spectroscopy

DD Shanbhag, TA Altes, GW Miller… - Journal of Magnetic …, 2006 - Wiley Online Library
Purpose To examine the utility of a 3He spectroscopic q‐space technique for detecting
changes in lung morphometry in vivo. Materials and Methods A diffusion‐weighted …

Lung morphometry using hyperpolarized 129Xe multi‐b diffusion MRI with compressed sensing in healthy subjects and patients with COPD

H Zhang, J Xie, S Xiao, X Zhao, M Zhang, L Shi… - Medical …, 2018 - Wiley Online Library
Purpose To demonstrate the feasibility of compressed sensing (CS) to accelerate the
acquisition of hyperpolarized (HP) 129Xe multi‐b diffusion MRI for quantitative assessments …

Rapid single‐breath hyperpolarized noble gas MRI‐based biomarkers of airspace enlargement

A Westcott, F Guo, G Parraga… - Journal of Magnetic …, 2019 - Wiley Online Library
Background Multi‐b diffusion‐weighted hyperpolarized‐gas MRI measures pulmonary
airspace‐enlargement using apparent diffusion coefficients (ADCs) and mean‐linear …