Transplantation is a successful treatment for end-stage organ failure. Despite improvements
in short-term outcome, long-term survival remains suboptimal because of the morbidity and …

Owing to the adverse effects of immunosuppression and an inability to prevent chronic
rejection, there is a pressing need for alternative strategies to control alloimmunity. In three …

The concept of regulatory T cell (Treg) therapy in transplantation is now a reality. Significant
advances in science and technology have enabled us to isolate human Tregs, expand them …

Organ transplantation is the preferred treatment option for end-stage organ failure. Although
immunosuppressants are effective for preventing the occurrence of acute rejection, they also …

The major challenge in transplantation medicine remains long-term allograft acceptance,
with preserved allograft function under minimal chronic immunosuppression. To safely …

Regulatory T cells (Tregs) are critical mediators of immune homeostasis and hold significant
promise in the quest for transplantation tolerance. Progress has now reached a critical …

The discovery of regulatory T cells (Tregs) as a crucial component of peripheral down-
regulation of immunity to self and allogeneic antigens has raised legitimate hope for the …

Decreasing the incidence of chronic rejection and reducing the need for life-long
immunosuppression remain important goals in clinical transplantation. In this article, we will …

Regulatory T cells (Tregs) are important for the induction and maintenance of peripheral
tolerance therefore, they are key in preventing excessive immune responses and …

Solid organ transplantation is the treatment of choice for patients with end-stage organ
dysfunction. Despite improvements in short-term outcome, long-term outcome is suboptimal …