Organ transplantation is currently the only effective treatment for end-stage organ failure.
However, success is limited by the immune response of the recipient to allogeneic tissues …

Although many key questions about Tregs remain, we are undoubtedly entering an exciting
era of Treg research in clinical transplantation. As renewed efforts focus on translational …

Transplantation tolerance is the ultimate goal of organ transplantation. Natural regulatory T
cells (Treg) have been expected to reach clinical applications for tolerance induction …

Advances in immunosuppressive therapies have made tissue and organ transplantation a
common procedure in clinical medicine. However, true donor and recipient tolerance is not …

Solid organ transplantation is the treatment of choice for patients with end‐stage organ
failure. To prevent rejection of the transplanted organ continuous treatment with …

Three main types of CD4+ regulatory T cells can be distinguished based upon whether they
express Foxp3 and differentiate naturally in the thymus (natural Tregs) or are induced in the …

In recent years, regulatory T (Treg) cells have reached centre-stage in immune tolerance
research. A role for Treg cells in preventing autoimmunity or generating transplantation …

Regulatory T cells (Tregs) are essential to transplantation tolerance and their therapeutic
efficacy is well documented in animal models. Moreover, human Tregs can be identified …

The adoptive transfer of donor-type CD4+ CD25+ FOXP3+ regulatory T cells (Treg) protects
from graft-versus-host disease in murine bone marrow transplantation models. Results from …

T regulatory cells (Tregs) play a vital role in suppressing heightened immune response, and
thereby promote a state of immunological tolerance. Tregs modulate both innate and …