Protein homeostasis or proteostasis is an essential balance of cellular protein levels
mediated through an extensive network of biochemical pathways that regulate different …

The term proteostasis reflects the fine-tuned balance of cellular protein levels, mediated
through a vast network of biochemical pathways. This requires the regulated control of …

Protein homeostasis (proteostasis) disturbances and inflammation are evident in normal
aging and some age-related neurodegenerative diseases. While the proteostasis network …

Genetic and environmental factors responsible for numerous neurodegenerative diseases
vary between disorders, yet age remains a universal risk factor. Age-associated decline in …

Ensuring cellular protein homeostasis, or proteostasis, requires precise control of protein
synthesis, folding, conformational maintenance, and degradation. A complex and adaptive …

Protein homeostasis, or proteostasis, is crucial for the functioning of a cell, as proteins that
are mislocalized, present in excessive amounts, or aberrant due to misfolding or other type …

Control of proper protein synthesis, function, and turnover is essential for the health of all
cells. In neurons these demands take on the additional importance of supporting and …

A common characteristic of neurodegenerative diseases like Alzheimer's disease (AD),
Parkinson's disease (PD) and Huntington's disease (HD) is the accumulation of protein …

Oxidative stress occurs in a variety of disease settings and is strongly linked to the
development of neuron death and neuronal dysfunction. Cells are equipped with numerous …

Intracellular proteolysis is critical to maintain timely degradation of altered proteins including
oxidized proteins. This review attempts to summarize the most relevant findings about …