Effect of fecal microbiota transplantation on neurological restoration in a spinal cord injury mouse model: involvement of brain-gut axis

Y Jing, Y Yu, F Bai, L Wang, D Yang, C Zhang, C Qin… - Microbiome, 2021 - Springer
Background Spinal cord injury (SCI) patients display disruption of gut microbiome, and gut
dysbiosis exacerbate neurological impairment in SCI models. Cumulative data support an …

Fecal microbiota transplantation exerts neuroprotective effects in a mouse spinal cord injury model by modulating the microenvironment at the lesion site

Y Jing, F Bai, L Wang, D Yang, Y Yan… - Microbiology …, 2022 - Am Soc Microbiol
The primary traumatic event that causes spinal cord injury (SCI) is followed by a progressive
secondary injury featured by vascular disruption and ischemia, inflammatory responses and …

Fecal microbiota transplantation is a promising method to restore gut microbiota dysbiosis and relieve neurological deficits after traumatic brain injury

D Du, W Tang, C Zhou, X Sun, Z Wei… - Oxidative medicine …, 2021 - Wiley Online Library
Background. Traumatic brain injury (TBI) can induce persistent fluctuation in the gut
microbiota makeup and abundance. The present study is aimed at determining whether …

Alterations in gut microbiota are related to metabolite profiles in spinal cord injury

JN Kang, ZF Sun, XY Li, XD Zhang, ZX Jin… - Neural Regeneration …, 2023 - journals.lww.com
Studies have shown that gut microbiota metabolites can enter the central nervous system via
the blood-spinal cord barrier and cause neuroinflammation, thus constituting secondary …

Gut dysbiosis impairs recovery after spinal cord injury

KA Kigerl, JCE Hall, L Wang, X Mo, Z Yu… - Journal of Experimental …, 2016 - rupress.org
The trillions of microbes that exist in the gastrointestinal tract have emerged as pivotal
regulators of mammalian development and physiology. Disruption of this gut microbiome, a …

Spinal cord injury and gut microbiota: A review

Y Jing, F Bai, Y Yu - Life sciences, 2021 - Elsevier
After spinal cord injury (SCI), intestinal dysfunction has a serious impact on physical and
mental health, quality of life, and social participation. Recent data from rodent and human …

Investigation of microbiota alterations and intestinal inflammation post-spinal cord injury in rat model

G O'Connor, E Jeffrey, D Madorma, A Marcillo… - Journal of …, 2018 - liebertpub.com
Although there has been a significant amount of research focused on the pathophysiology of
spinal cord injury (SCI), there is limited information on the consequences of SCI on remote …

The microbiota-gut-brain axis participates in chronic cerebral hypoperfusion by disrupting the metabolism of short-chain fatty acids

W Xiao, J Su, X Gao, H Yang, R Weng, W Ni, Y Gu - Microbiome, 2022 - Springer
Background Chronic cerebral hypoperfusion (CCH) underlies secondary brain injury
following certain metabolic disorders and central nervous system (CNS) diseases …

Gut microbiota as a therapeutic target to ameliorate the biochemical, neuroanatomical, and behavioral effects of traumatic brain injuries

MW Rice, JD Pandya, DA Shear - Frontiers in neurology, 2019 - frontiersin.org
Current efficacious treatments for traumatic brain injury (TBI) are lacking. Establishment of a
protective gut microbiota population offers a compelling therapeutic avenue, as brain injury …

Traumatic spinal cord injury and the gut microbiota: current insights and future challenges

T Jogia, MJ Ruitenberg - Frontiers in immunology, 2020 - frontiersin.org
Individuals with traumatic spinal cord injury (SCI) suffer from numerous peripheral
complications in addition to the long-term paralysis that results from disrupted neural …