Hypertension is now considered as an inflammatory disease, and the kidney is a key end-
organ target. Experimental and clinical studies suggest that interleukin 17A (IL-17A) is a …

Abstract Purpose of Review To summarize key advances in our understanding of the role of
interleukin 17A (IL-17A) in the pathogenesis of hypertension and highlight important areas …

Cytokines are necessary to trigger the inflammatory response in kidney
ischemia/reperfusion injury. Interleukin-17C (IL-17C), a unique member of the IL-17 family …

Angiotensin II–induced hypertension is associated with an increase in T-cell production of
interleukin-17A (IL-17A). Recently, we reported that IL-17A−/− mice exhibit blunted …

Being a member of the IL-17 family, comprising six structurally related ligands, IL-17A is a
cytokine, produced by multiple cell types, such as CD4+ αβ T cells, γδ T cells, natural killer …

The role of the pro-inflammatory cytokine IL-17 in the pathogenesis of numerous
inflammatory disorders is well-documented, but conflicting results are reported for its role in …

The TH 17 immune response has a central role in the pathogenesis of autoimmune
diseases, implicating the TH 17 master cytokine, IL-17A, as the critical mediator of diseases …

The kidney is an organ particularly susceptible to damage caused by infections and
autoimmune conditions. Renal inflammation confers protection against microbial infections …

An important link exists between hypertension and inflammation. Hypertensive patients
present elevated circulating levels of proinflammatory cytokines, including interleukin-17A …

Current knowledge suggests that hypertension is in part mediated by immune mechanisms.
Both interleukin (IL)-23 and IL-17 are up-regulated in several experimental hypertensive …