IL-36, a newly named member of the IL-1 cytokine family, includes 3 isoforms, IL-36α, IL-
36β, and IL-36γ, all of which bind to a heterodimer containing the IL-36 receptor (IL-36R) …

Both acute and chronic kidney disease have a strong underlying inflammatory component.
This review focuses primarily on T helper 17 (Th17) cells as mediators of inflammation and …

Experimental crescentic glomerulonephritis (GN) is characterized by T helper 1 (Th1)
directed nephritogenic immune responses and cell-mediated glomerular injury. IL-12p40 …

Interleukin (IL)-15 serves as a survival factor for a broad array of cells. Renal cells express
both IL-15 and its receptor (IL-15R); however, the role of IL-15 in the kidney is yet to be …

The inflammatory response has an important role in the pathophysiology of diabetic
nephropathy that is contributed to by inflammatory mediators such as interleukin‐1 (IL‐1), IL …

Background/Aims: Interleukin-17A (IL-17A) is a T cell-derived inflammatory cytokine that is
upregulated during renal allograft rejection. The present study sought to further describe the …

T and B cells have been implicated in hypertension, but the mechanisms by which they
produce a coordinated response is unknown. T follicular helper (Tfh) cells that produce IL-21 …

Interleukin (IL) 17 is a novel cytokine that has been suggested to play a key role in
sustaining chronic inflammation in autoimmune diseases. Since its discovery, much …

Atherosclerosis is a chronic inflammatory disease. Lesion progression is primarily mediated
by cells of the monocyte/macrophage lineage. IL-17A is a proinflammatory cytokine, which …

The kidney contains receptors for the cytokine IL-25, but the effects of IL-25 in CKD are
unknown. Here, we induced adriamycin nephropathy in both BALB/c mice and severe …