Background: Androgens play an essential role in the development and differentiation of the
prostate gland; their contribution to pathological conditions, such as benign prostatic …

CONTEXT: The traditional belief that prostate cancer (PCa) growth is dependent on serum
testosterone (T) level has been challenged by recent negative studies in noncastrated men …

Although androgen receptor signaling is critical for prostate cancer growth and survival,
evidence supporting a favorable risk–benefit ratio of androgen deprivation therapy (ADT) is …

The prostate is an androgen-dependent organ that develops only in male mammals.
Prostate cancer is the most common nonskin malignancy in men and the second leading …

Almost all men who present with advanced prostate cancer (CaP) and many men who fail
potentially curative therapy are treated with androgen deprivation therapy (ADT). ADT is not …

Prostate carcinoma is the most frequently diagnosed malignancy and the second leading
cause of death as a result of cancer in men in the western countries. Withdrawal of …

A growing body of literature has established the anabolic benefits of testosterone (T) therapy
in hypogonadal men. However, there remains a paucity of data regarding the risks of …

This review is triggered by recent developments that offer new explanations for the
mechanism of progression of prostate cancer to androgen independence. Established and …

Background Prostate cancer continues to be the most common lethal malignancy diagnosed
in American men and the second leading cause of male cancer mortality. The American …

Androgen replacement therapy in the aging male with partial androgen deficiency improved
quality of life. However, such treatment is prohibited for men with a preexisting prostate …