Mechanism and regulation of co-transcriptional mRNP assembly and nuclear mRNA export

W Wende, P Friedhoff, K Sträßer - The biology of mRNA: structure and …, 2019 - Springer
Abstract mRNA is the “hermes” of gene expression as it carries the information of a protein-
coding gene to the ribosome. Already during its synthesis, the mRNA is bound by mRNA …

Cotranscriptional mRNP assembly: from the DNA to the nuclear pore

A Aguilera - Current opinion in cell biology, 2005 - Elsevier
Transcription is coupled with the concomitant assembly of RNA-binding proteins to the
nascent mRNA to generate a stable and export-competent mRNP particle. RNA-binding …

Biogenesis of mRNPs: integrating different processes in the eukaryotic nucleus

R Luna, H Gaillard, C González-Aguilera, A Aguilera - Chromosoma, 2008 - Springer
Transcription is a central function occurring in the nucleus of eukaryotic cells in coordination
with other nuclear processes. During transcription, the nascent pre-mRNA associates with …

Co‐transcriptional mRNP formation is coordinated within a molecular mRNP packaging station in S. cerevisiae

DM Meinel, K Sträßer - Bioessays, 2015 - Wiley Online Library
In eukaryotes, the messenger RNA (mRNA), the blueprint of a protein‐coding gene, is
processed and packaged into a messenger ribonucleoprotein particle (mRNP) by mRNA …

Keeping mRNPs in check during assembly and nuclear export

E Tutucci, F Stutz - Nature reviews Molecular cell biology, 2011 - nature.com
The cell nucleus is an intricate organelle that coordinates multiple activities that are
associated with DNA replication and gene expression. In all eukaryotes, it stores the genetic …

How cells get the message: dynamic assembly and function of mRNA–protein complexes

M Müller-McNicoll, KM Neugebauer - Nature Reviews Genetics, 2013 - nature.com
Abstract mRNA is packaged into ribonucleoprotein particles called mRNPs. A multitude of
RNA-binding proteins as well as a host of associated proteins participate in the fate of …

[HTML][HTML] Early formation of mRNP: license for export or quality control?

TH Jensen, K Dower, D Libri, M Rosbash - Molecular cell, 2003 - cell.com
Eukaryotic mRNA is processed by enzymes and packaged with proteins within nuclei to
generate functional messenger ribonucleoprotein (mRNP) particles. Processing and …

The landscape of eukaryotic mRNPs

A Khong, R Parker - Rna, 2020 - rnajournal.cshlp.org
The proper regulation of mRNA processing, localization, translation, and degradation occurs
on mRNPs. However, the global principles of mRNP organization are poorly understood. We …

[HTML][HTML] Regulation of mRNA trafficking by nuclear pore complexes

A Bonnet, B Palancade - Genes, 2014 - mdpi.com
Over the last two decades, multiple studies have explored the mechanisms governing
mRNA export out of the nucleus, a crucial step in eukaryotic gene expression. During …

[HTML][HTML] Spatial organization of single mRNPs at different stages of the gene expression pathway

S Adivarahan, N Livingston, B Nicholson, S Rahman… - Molecular cell, 2018 - cell.com
Summary mRNAs form ribonucleoprotein complexes (mRNPs) by association with proteins
that are crucial for mRNA metabolism. While the mRNP proteome has been well …