Functional cytokine networks have been poorly characterized in systemic sclerosis (SSc).
While interleukin-17A (IL-17A) is increased in SSc skin and other organs, its role is still …

Objective Systemic sclerosis (SSc) is a progressive fibrotic disease that affects the skin and
internal organs. Despite evidence implicating increased interleukin-17 (IL-17) activity in SSc …

IL-17A is abundant in scleroderma but its role in fibrogenesis is controversial. We
interrogated the role of IL-17A in extracellular matrix deposition and inflammation by …

Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of skin and
internal organs. Its pathogenesis, which is still poorly understood, features three main …

Objective Levels of interleukin‐17A (IL‐17A) have been found to be increased in synovial
fluid from individuals with systemic sclerosis (SSc). This study was undertaken to investigate …

Background High interleukin (IL)-17A levels are characteristically found in the skin of
systemic sclerosis (SSc) individuals. Our aim was to investigate whether the dermal …

Systemic sclerosis (SSc) is a chronic multisystem disorder characterized by fibrosis and
autoimmunity. Interleukin (IL)-31 has been implicated in fibrosis and T helper (Th) 2 immune …

In systemic sclerosis (SSc) immuno-inflammatory events are central to disease
development. Amongst other mediators of inflammation, interleukin 17 (IL-17) and Th17 …

Objectives Cytokines released by infiltrating T cells may promote mechanisms leading to
fibrosis in scleroderma. The aim of this study was to investigate the role of the Th2 cytokine …

Abstract Among IL-17 families, IL-17A and IL-17F share amino acid sequence similarity and
bind to IL-17R type A. IL-17 signaling is implicated in the pathogenesis of various …