The TH 17 immune response has a central role in the pathogenesis of autoimmune
diseases, implicating the TH 17 master cytokine, IL-17A, as the critical mediator of diseases …

Background IL-17A–producing CD4+ T helper (TH 17) cells play a critical role in
autoimmune and chronic inflammatory diseases, such as crescentic GN. The …

Immune-mediated glomerular diseases (glomerulonephritis) encompass a heterogeneous
collection of diseases that cause inflammation within the glomerulus and other renal …

The IL-17 cytokine family and the cognate receptors thereof have a unique role in organ-
specific autoimmunity. Most studies have focused on the founding member of the IL-17 …

T helper (Th) 17 cells might contribute to immune-mediated renal injury. Thus, we sought to
define the time course of IL-17A-induced kidney damage and examined the relation …

The Th17 immune response appears to contribute to the pathogenesis of human and
experimental crescentic GN, but the cell types that produce IL-17A in the kidney, the …

In recent years, proinflammatory cytokines in the nephritic kidney appear to contribute to the
pathogenesis of AGN. The complex inflammatory cytokine network that drives renal …

The kidney is an organ particularly susceptible to damage caused by infections and
autoimmune conditions. Renal inflammation confers protection against microbial infections …

T cells infiltrate the kidney in both human and experimental glomerulonephritis, and several
lines of evidence indicate that T cell-mediated tissue damage plays an important role in the …

Interleukin-17A (IL-17) promotes inflammatory renal tissue damage in mouse models of
crescentic glomerulonephritis, including murine experimental autoimmune anti …