Background Patients with systemic lupus erythematosus (SLE) are highly susceptible to
infection and cardiovascular events, suggesting that chronic antigenic stimulation may …

Clinical and experimental studies have established that immune cells such as alternatively
activated (M2) macrophages and Th17 cells play a role in the progression of chronic kidney …

Crescentic glomerulonephritis (cGN) is a severe clinical manifestation in a subset of patients
with Systemic lupus erythematosus. Lack of understanding of the pathogenesis of cGN act …

Experimental crescentic glomerulonephritis (GN) is characterized by T helper 1 (Th1)
directed nephritogenic immune responses and cell-mediated glomerular injury. IL-12p40 …

IL-13 is produced by T helper 2 (Th2) cells, has a role in stimulating Th2-mediated injury,
alters humoral responses, and may directly suppress macrophage and neutrophil function …

Summary Background Interleukin-17C (IL-17C), a member of the IL-17 cytokine family, plays
a pathogenic role in kidney diseases. Our previous studies have shown that pre …

The role of the pro-inflammatory cytokine IL-17 in the pathogenesis of numerous
inflammatory disorders is well-documented, but conflicting results are reported for its role in …

Objective The CD4+ T cell immune response plays a pivotal role in the
immunopathogenesis of human and experimental lupus nephritis, but the contribution of the …

IL-17–producing T cells infiltrate kidneys of patients with lupus nephritis, and IL-23–treated
lymph node cells from lupus-prone mice may transfer disease to Rag1-deficient mice. In this …

Different T cell subsets have been implicated in the pathogenesis of glomerulonephritis.
Several lines of evidence indicate the recently identified interleukin-17 (IL-17)-producing T …