Excessive IL-15 promotes cytotoxic CD4+ CD28− T cell-mediated renal injury in lupus nephritis
T Zhang, X Liu, Y Zhao, X Xu, Y Liu, X Wu - Immunity & Ageing, 2022 - Springer
Background Patients with systemic lupus erythematosus (SLE) are highly susceptible to
infection and cardiovascular events, suggesting that chronic antigenic stimulation may …
infection and cardiovascular events, suggesting that chronic antigenic stimulation may …
Loss of IL-27Rα results in enhanced tubulointerstitial fibrosis associated with elevated Th17 responses
Clinical and experimental studies have established that immune cells such as alternatively
activated (M2) macrophages and Th17 cells play a role in the progression of chronic kidney …
activated (M2) macrophages and Th17 cells play a role in the progression of chronic kidney …
Interleukin 17 signaling drives Type I Interferon induced proliferative crescentic glomerulonephritis in lupus-prone mice
Crescentic glomerulonephritis (cGN) is a severe clinical manifestation in a subset of patients
with Systemic lupus erythematosus. Lack of understanding of the pathogenesis of cGN act …
with Systemic lupus erythematosus. Lack of understanding of the pathogenesis of cGN act …
IL-12p40 and IL-18 in crescentic glomerulonephritis: IL-12p40 is the key Th1-defining cytokine chain, whereas IL-18 promotes local inflammation and leukocyte …
AR Kitching, AL Turner, GRA Wilson… - Journal of the …, 2005 - journals.lww.com
Experimental crescentic glomerulonephritis (GN) is characterized by T helper 1 (Th1)
directed nephritogenic immune responses and cell-mediated glomerular injury. IL-12p40 …
directed nephritogenic immune responses and cell-mediated glomerular injury. IL-12p40 …
Endogenous IL-13 limits humoral responses and injury in experimental glomerulonephritis but does not regulate Th1 cell-mediated crescentic glomerulonephritis
AR Kitching, AL Turner, GRA Wilson… - Journal of the …, 2004 - journals.lww.com
IL-13 is produced by T helper 2 (Th2) cells, has a role in stimulating Th2-mediated injury,
alters humoral responses, and may directly suppress macrophage and neutrophil function …
alters humoral responses, and may directly suppress macrophage and neutrophil function …
IL-17C neutralization protects the kidney against acute injury and chronic injury
F Zhang, J Yin, L Liu, S Liu, G Zhang, Y Kong… - …, 2023 - thelancet.com
Summary Background Interleukin-17C (IL-17C), a member of the IL-17 cytokine family, plays
a pathogenic role in kidney diseases. Our previous studies have shown that pre …
a pathogenic role in kidney diseases. Our previous studies have shown that pre …
Interleukin 17A promotes diabetic kidney injury
J Ma, YJ Li, X Chen, T Kwan, SJ Chadban, H Wu - Scientific reports, 2019 - nature.com
The role of the pro-inflammatory cytokine IL-17 in the pathogenesis of numerous
inflammatory disorders is well-documented, but conflicting results are reported for its role in …
inflammatory disorders is well-documented, but conflicting results are reported for its role in …
Function of the Th17/interleukin‐17A immune response in murine lupus nephritis
T Schmidt, HJ Paust, CF Krebs, JE Turner… - Arthritis & …, 2015 - Wiley Online Library
Objective The CD4+ T cell immune response plays a pivotal role in the
immunopathogenesis of human and experimental lupus nephritis, but the contribution of the …
immunopathogenesis of human and experimental lupus nephritis, but the contribution of the …
Cutting edge: IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL/6–lpr/lpr mice
VC Kyttaris, Z Zhang, VK Kuchroo, M Oukka… - The Journal of …, 2010 - journals.aai.org
IL-17–producing T cells infiltrate kidneys of patients with lupus nephritis, and IL-23–treated
lymph node cells from lupus-prone mice may transfer disease to Rag1-deficient mice. In this …
lymph node cells from lupus-prone mice may transfer disease to Rag1-deficient mice. In this …
Emerging roles of the Th17/IL-17-axis in glomerulonephritis
Different T cell subsets have been implicated in the pathogenesis of glomerulonephritis.
Several lines of evidence indicate the recently identified interleukin-17 (IL-17)-producing T …
Several lines of evidence indicate the recently identified interleukin-17 (IL-17)-producing T …