Systemic lupus erythematosus (SLE) is mediated by a chronic and dysregulated
inflammatory response. Interleukin (IL)-17, a proinflammatory cytokine, and T helper (Th) 17 …

In acute kidney injury, which is a significant cause of morbidity and mortality, cytokines and
leukocytes promote inflammation and injury. We examined the pathogenic role of IL-17A in …

A major target autoantigen in anti-neutrophil cytoplasmic antibody–associated vasculitis is
myeloperoxidase (MPO). Although MPO-specific CD4+ Th cells seem to orchestrate renal …

Diabetic nephropathy (DN) is the most common cause of ESRD in the United States. Current
standard of care for patients with DN can slow the progression of DN, but there are no …

Despite its initially defined role as a T-helper type 1 cell (Th1)–inducing cytokine, interleukin-
27 (IL-27) has complex roles in vivo. The role of IL-27 receptor (IL-27R) was defined in …

Lupus nephritis (LN) is one of the most severe manifestations of systemic lupus
erythematosus (SLE). Our previous studies demonstrated increased serum and renal …

The autoantigen in Goodpasture disease is the noncollagenous domain of α3 type IV
collagen [α3 (IV) NC1]. We previously demonstrated that IL-12p40−/− mice are protected …

The discovery of interleukin (IL)-17-producing CD4+ T (Th17) cells as a unique T-helper cell
lineage has revised our understanding of T-cell-mediated tissue injury. Recent data from …

Background Th17 cells are central pathogenic mediators of autoimmune disease, including
many forms of GN. IL-10 receptor signaling (IL-10R) in regulatory T cells (Tregs) has been …

Rapid progressive glomerulonephritis (GN) often leads to end-stage kidney disease, driving
the need for renal replacement therapy and posing a global health burden. Low-dose …