IL-25 is an important immune regulator that can promote Th2 immune response-dependent
immunity, inflammation, and tissue repair in asthma, intestinal infection, and autoimmune …

Diabetic nephropathy (DN) is one of the most common complications of diabetes, and
currently the first end-stage renal disease worldwide. New strategies to treat DN using …

Interleukin 17A-secreting T-helper 17 (Th17) cells are pathogenic in inflammatory kidney
diseases, but their intrarenal regulation is poorly understood. In order to better define Th17 …

T helper type 17 (Th17) cells, a novel distinct subset of Th cell, can secrete interleukin (IL)-
17 in humans. Although recent data suggest that Th17 cells and IL-17 play an important role …

Chronic kidney disease has become a major medical issue in recent years due to its high
prevalence worldwide, its association with premature mortality, and its social and economic …

Abstract Interleukin (IL)-18 is a proinflammatory cytokine produced by leukocytes and
parenchymal cells (eg, tubular epithelial cells (TECs), mesangial cells, and podocytes). IL …

Studies show that the Th17/IL‐17A axis plays an important role in the pathogenesis of
kidney diseases. Previously, we also showed that IL‐17A may play a role in the …

Systemic lupus erythematosus (SLE) is an autoimmune disorder that is associated with
lupus nephritis, initiated by the deposition of immune complexes in the kidney; …

Although Th17 responses may contribute to the pathogenesis of glomerulonephritis,
whether the key transcription factor in Th17 cell development, RORγt, also promotes …

Endogenous interleukin-10 regulates Th1 responses that induce crescentic
glomerulonephritis. Background Interleukin (IL)-10 plays a pivotal role in regulating the …