Context: T helper (Th) cells as an important part of the immune is responsible for elimination
of invading pathogens. But, if Th cell responses are not regulated effectively, the …

Autoimmune disease in MRL-Fas lpr mice is characterized by fatal nephritis, systemic
pathology, and autoantibodies, mimicking human lupus. We previously reported that 1) …

IL-17C, which is a member of the IL-17 family of cytokines, is preferentially produced by
epithelial cells in the lung, skin and colon, suggesting that IL-17C may be involved in not …

Immune-mediated kidney diseases are a leading cause of end-stage renal disease. Despite
recent discoveries, the immunopathogenesis of this heterogeneous disease group remains …

Objective Diabetic nephropathy (DN) is a leading cause of end-stage renal disease. Since
there are limited therapeutic options available for the prevention of DN progression, it is …

Interleukins have become well-known regulators of innate and adaptive immunity-related
tissue inflammation. Recently, IL-22 has gained a lot of interest for its unique functions in …

Interstitial kidney inflammation is present in various nephritides in which serum interleukin
23 (IL-23) is elevated. Here we showed that murine and human renal tubular epithelial cells …

Abstract Interleukin-12 (IL-12) directs the cognate nephritogenic T helper type 1 responses
that initiate renal injury in murine crescentic glomerulonephritis (GN). The recent …

Chronic kidney disease and its complications are a major public health problem worldwide.
Diabetic nephropathy has become the main contributing cause of terminal renal failure …

Glomerular crescent formation characterizes severe glomerulonephritis (GN). Evidence
suggests that crescent formation results from a delayed‐type hypersensitivity‐like Th1 …